Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
Date
Authors
Cortez, Nicole
Villegas, Cecilia
Burgos, Viviana
Ortíz, Leandro
Cabrera-Pardo, Jaime R.
Paz, Cristian
Villegas, Cecilia
Burgos, Viviana
Ortíz, Leandro
Cabrera-Pardo, Jaime R.
Paz, Cristian
Authors
Date
Datos de publicación:
10.3390/ijms25105189
Keywords
Cga - Chemoresistance - Chemotherapy-induced Toxicity - Chlorogenic Acid - Chlorogenic Acid - Cisplatin - Doxorubicin - Fluorouracil - Neochlorogenic Acid - Oxaliplatin - Regorafenib - Antineoplastic Agents - Chlorogenic Acid - Chlorogenic Acid - Cisplatin - Doxorubicin - Fluorouracil - Neochlorogenic Acid - Oxaliplatin - Regorafenib - Antineoplastic Agent - Animal Experiment - Animal Model - Antineoplastic Activity - Biosynthesis - Cancer Inhibition - Cancer Therapy - Drug Resistance - In Vitro Study - Inflammation - Mouse - Nonhuman - Review - Tumor Resistance - Vegetable - Animal - Drug Effect - Drug Therapy - Human - Metabolism - Neoplasm - Animals - Antineoplastic Agents - Chlorogenic Acid - Drug Resistance, Neoplasm - Humans - Neoplasms - Ácido clorogénico - CGA - Quimiorresistencia - Toxicidad inducida por quimioterapia
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Abstract
Chemotherapeutic drugs are indispensable in cancer treatment, but their effectiveness is often lessened because of non-selective toxicity to healthy tissues, which triggers inflammatory pathways that are harmful to vital organs. In addition, tumors resistance to drugs causes failures in treatment. Chlorogenic acid (5-caffeoylquinic acid, CGA), found in plants and vegetables, is promising in anticancer mechanisms. In vitro and animal studies have indicated that CGA can overcome resistance to conventional chemotherapeutics and alleviate chemotherapy-induced toxicity by scavenging free radicals effectively. This review is a summary of current information about CGA, including its natural sources, biosynthesis, metabolism, toxicology, role in combatting chemoresistance, and protective effects against chemotherapy-induced toxicity. It also emphasizes the potential of CGA as a pharmacological adjuvant in cancer treatment with drugs such as 5-fluorouracil, cisplatin, oxaliplatin, doxorubicin, regorafenib, and radiotherapy. By analyzing more than 140 papers from PubMed, Google Scholar, and SciFinder, we hope to find the therapeutic potential of CGA in improving cancer therapy. © 2024 Elsevier B.V., All rights reserved.
Description
Keywords
Cga , Chemoresistance , Chemotherapy-induced Toxicity , Chlorogenic Acid , Chlorogenic Acid , Cisplatin , Doxorubicin , Fluorouracil , Neochlorogenic Acid , Oxaliplatin , Regorafenib , Antineoplastic Agents , Chlorogenic Acid , Chlorogenic Acid , Cisplatin , Doxorubicin , Fluorouracil , Neochlorogenic Acid , Oxaliplatin , Regorafenib , Antineoplastic Agent , Animal Experiment , Animal Model , Antineoplastic Activity , Biosynthesis , Cancer Inhibition , Cancer Therapy , Drug Resistance , In Vitro Study , Inflammation , Mouse , Nonhuman , Review , Tumor Resistance , Vegetable , Animal , Drug Effect , Drug Therapy , Human , Metabolism , Neoplasm , Animals , Antineoplastic Agents , Chlorogenic Acid , Drug Resistance, Neoplasm , Humans , Neoplasms , Ácido clorogénico , CGA , Quimiorresistencia , Toxicidad inducida por quimioterapia
Citation
10.3390/ijms25105189