Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment

Simple item page
datacite.alternateIdentifier.citationInternational Journal of Molecular Sciences, 25 (10), 2024
datacite.alternateIdentifier.doi10.3390/ijms25105189
datacite.alternateIdentifier.issn1422-0067
datacite.creatorCortez, Nicole
datacite.creatorVillegas, Cecilia
datacite.creatorBurgos, Viviana
datacite.creatorOrtíz, Leandro
datacite.creatorCabrera-Pardo, Jaime R.
datacite.creatorPaz, Cristian
datacite.date2024
datacite.rightsAcceso abierto
datacite.subjectCga
datacite.subjectChemoresistance
datacite.subjectChemotherapy-induced Toxicity
datacite.subjectChlorogenic Acid
datacite.subjectChlorogenic Acid
datacite.subjectCisplatin
datacite.subjectDoxorubicin
datacite.subjectFluorouracil
datacite.subjectNeochlorogenic Acid
datacite.subjectOxaliplatin
datacite.subjectRegorafenib
datacite.subjectAntineoplastic Agents
datacite.subjectChlorogenic Acid
datacite.subjectChlorogenic Acid
datacite.subjectCisplatin
datacite.subjectDoxorubicin
datacite.subjectFluorouracil
datacite.subjectNeochlorogenic Acid
datacite.subjectOxaliplatin
datacite.subjectRegorafenib
datacite.subjectAntineoplastic Agent
datacite.subjectAnimal Experiment
datacite.subjectAnimal Model
datacite.subjectAntineoplastic Activity
datacite.subjectBiosynthesis
datacite.subjectCancer Inhibition
datacite.subjectCancer Therapy
datacite.subjectDrug Resistance
datacite.subjectIn Vitro Study
datacite.subjectInflammation
datacite.subjectMouse
datacite.subjectNonhuman
datacite.subjectReview
datacite.subjectTumor Resistance
datacite.subjectVegetable
datacite.subjectAnimal
datacite.subjectDrug Effect
datacite.subjectDrug Therapy
datacite.subjectHuman
datacite.subjectMetabolism
datacite.subjectNeoplasm
datacite.subjectAnimals
datacite.subjectAntineoplastic Agents
datacite.subjectChlorogenic Acid
datacite.subjectDrug Resistance, Neoplasm
datacite.subjectHumans
datacite.subjectNeoplasms
datacite.subjectÁcido clorogénicoes
datacite.subjectCGAes
datacite.subjectQuimiorresistenciaes
datacite.subjectToxicidad inducida por quimioterapiaes
datacite.titleTherapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
dc.date.accessioned2025-10-06T14:21:55Z
dc.date.available2025-10-06T14:21:55Z
dc.description.abstractChemotherapeutic drugs are indispensable in cancer treatment, but their effectiveness is often lessened because of non-selective toxicity to healthy tissues, which triggers inflammatory pathways that are harmful to vital organs. In addition, tumors resistance to drugs causes failures in treatment. Chlorogenic acid (5-caffeoylquinic acid, CGA), found in plants and vegetables, is promising in anticancer mechanisms. In vitro and animal studies have indicated that CGA can overcome resistance to conventional chemotherapeutics and alleviate chemotherapy-induced toxicity by scavenging free radicals effectively. This review is a summary of current information about CGA, including its natural sources, biosynthesis, metabolism, toxicology, role in combatting chemoresistance, and protective effects against chemotherapy-induced toxicity. It also emphasizes the potential of CGA as a pharmacological adjuvant in cancer treatment with drugs such as 5-fluorouracil, cisplatin, oxaliplatin, doxorubicin, regorafenib, and radiotherapy. By analyzing more than 140 papers from PubMed, Google Scholar, and SciFinder, we hope to find the therapeutic potential of CGA in improving cancer therapy. © 2024 Elsevier B.V., All rights reserved.
dc.description.ia_keywordcancer, treatment, drugs, toxicity, acid, potential, resistance
dc.formatPDF
dc.identifier.issn1661-6596
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6865
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourceInternational Journal of Molecular Sciences
dc.subject.ia_oecd1nCiencias Médicas y de la Salud
dc.subject.ia_oecd2nMedicina Clínica
dc.subject.ia_oecd3nMedicina Clínica
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2024
oaire.citationIssue10
oaire.citationTitleInternational Journal of Molecular Sciences
oaire.citationVolume25
oaire.fundingReferenceANID FONDECYT 1220831
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo de revisión
oaire.resourceType.enReview
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Biológicas y Químicas
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed Central (PMC)
uct.indizacionChemical Abstracts Service (CAS)
uct.indizacionMEDLINE
Files
Collections
Producción Alimentaria