Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
Date
Authors
Villegas, Cecilia
Cortez, Nicole
Ogundele, Ayorinde Victor
Burgos, Viviana
Pardi, Paulo Celso
Cabrera-Pardo, Jaime R.
Paz, Cristian
Cortez, Nicole
Ogundele, Ayorinde Victor
Burgos, Viviana
Pardi, Paulo Celso
Cabrera-Pardo, Jaime R.
Paz, Cristian
Authors
Date
Datos de publicación:
10.3390/biom14070867
Keywords
Cancer Resistance - Chemoprotection - Chemotherapy Adjuvant - Rosmarinic Acid - Polyphenol - Rosmarinic Acid - Cinnamic Acid - Antineoplastic Agents - Antioxidants - Cinnamates - Depsides - Rosmarinic Acid - Antioxidant - Polyphenol - Rosmarinic Acid - Antineoplastic Agent - Cinnamic Acid - Depside - Adjuvant Chemotherapy - Adverse Drug Reaction - Alternative Medicine - Cancer Chemotherapy - Cancer Resistance - Controlled Study - Drug Resistance - Drug Therapy - Drug Toxicity - Human - Malignant Neoplasm - Nonhuman - Oral Drug Administration - Pharmacology - Radiotherapy - Review - Therapy - Treatment Failure - Animal - Chemistry - Drug Effect - Neoplasm - Animals - Antineoplastic Agents - Antioxidants - Cinnamates - Depsides - Drug Resistance, Neoplasm - Humans - Neoplasms - Rosmarinic Acid
Collections
Abstract
Chemotherapeutic drugs and radiotherapy are fundamental treatments to combat cancer, but, often, the doses in these treatments are restricted by their non-selective toxicities, which affect healthy tissues surrounding tumors. On the other hand, drug resistance is recognized as the main cause of chemotherapeutic treatment failure. Rosmarinic acid (RA) is a polyphenol of the phenylpropanoid family that is widely distributed in plants and vegetables, including medicinal aromatic herbs, consumption of which has demonstrated beneficial activities as antioxidants and anti-inflammatories and reduced the risks of cancers. Recently, several studies have shown that RA is able to reverse cancer resistance to first-line chemotherapeutics, as well as play a protective role against toxicity induced by chemotherapy and radiotherapy, mainly due to its scavenger capacity. This review compiles information from 56 articles from Google Scholar, PubMed, and ClinicalTrials.gov aimed at addressing the role of RA as a complementary therapy in cancer treatment. © 2024 Elsevier B.V., All rights reserved.
Description
Keywords
Cancer Resistance , Chemoprotection , Chemotherapy Adjuvant , Rosmarinic Acid , Polyphenol , Rosmarinic Acid , Cinnamic Acid , Antineoplastic Agents , Antioxidants , Cinnamates , Depsides , Rosmarinic Acid , Antioxidant , Polyphenol , Rosmarinic Acid , Antineoplastic Agent , Cinnamic Acid , Depside , Adjuvant Chemotherapy , Adverse Drug Reaction , Alternative Medicine , Cancer Chemotherapy , Cancer Resistance , Controlled Study , Drug Resistance , Drug Therapy , Drug Toxicity , Human , Malignant Neoplasm , Nonhuman , Oral Drug Administration , Pharmacology , Radiotherapy , Review , Therapy , Treatment Failure , Animal , Chemistry , Drug Effect , Neoplasm , Animals , Antineoplastic Agents , Antioxidants , Cinnamates , Depsides , Drug Resistance, Neoplasm , Humans , Neoplasms , Rosmarinic Acid
Citation
10.3390/biom14070867