Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity

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datacite.alternateIdentifier.citationBiomolecules, 14 (7), 2024
datacite.alternateIdentifier.doi10.3390/biom14070867
datacite.alternateIdentifier.issn2218-273X
datacite.creatorVillegas, Cecilia
datacite.creatorCortez, Nicole
datacite.creatorOgundele, Ayorinde Victor
datacite.creatorBurgos, Viviana
datacite.creatorPardi, Paulo Celso
datacite.creatorCabrera-Pardo, Jaime R.
datacite.creatorPaz, Cristian
datacite.date2024
datacite.rightsAcceso abierto
datacite.subjectCancer Resistance
datacite.subjectChemoprotection
datacite.subjectChemotherapy Adjuvant
datacite.subjectRosmarinic Acid
datacite.subjectPolyphenol
datacite.subjectRosmarinic Acid
datacite.subjectCinnamic Acid
datacite.subjectAntineoplastic Agents
datacite.subjectAntioxidants
datacite.subjectCinnamates
datacite.subjectDepsides
datacite.subjectRosmarinic Acid
datacite.subjectAntioxidant
datacite.subjectPolyphenol
datacite.subjectRosmarinic Acid
datacite.subjectAntineoplastic Agent
datacite.subjectCinnamic Acid
datacite.subjectDepside
datacite.subjectAdjuvant Chemotherapy
datacite.subjectAdverse Drug Reaction
datacite.subjectAlternative Medicine
datacite.subjectCancer Chemotherapy
datacite.subjectCancer Resistance
datacite.subjectControlled Study
datacite.subjectDrug Resistance
datacite.subjectDrug Therapy
datacite.subjectDrug Toxicity
datacite.subjectHuman
datacite.subjectMalignant Neoplasm
datacite.subjectNonhuman
datacite.subjectOral Drug Administration
datacite.subjectPharmacology
datacite.subjectRadiotherapy
datacite.subjectReview
datacite.subjectTherapy
datacite.subjectTreatment Failure
datacite.subjectAnimal
datacite.subjectChemistry
datacite.subjectDrug Effect
datacite.subjectNeoplasm
datacite.subjectAnimals
datacite.subjectAntineoplastic Agents
datacite.subjectAntioxidants
datacite.subjectCinnamates
datacite.subjectDepsides
datacite.subjectDrug Resistance, Neoplasm
datacite.subjectHumans
datacite.subjectNeoplasms
datacite.subjectRosmarinic Acid
datacite.titleTherapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
dc.description.abstractChemotherapeutic drugs and radiotherapy are fundamental treatments to combat cancer, but, often, the doses in these treatments are restricted by their non-selective toxicities, which affect healthy tissues surrounding tumors. On the other hand, drug resistance is recognized as the main cause of chemotherapeutic treatment failure. Rosmarinic acid (RA) is a polyphenol of the phenylpropanoid family that is widely distributed in plants and vegetables, including medicinal aromatic herbs, consumption of which has demonstrated beneficial activities as antioxidants and anti-inflammatories and reduced the risks of cancers. Recently, several studies have shown that RA is able to reverse cancer resistance to first-line chemotherapeutics, as well as play a protective role against toxicity induced by chemotherapy and radiotherapy, mainly due to its scavenger capacity. This review compiles information from 56 articles from Google Scholar, PubMed, and ClinicalTrials.gov aimed at addressing the role of RA as a complementary therapy in cancer treatment. © 2024 Elsevier B.V., All rights reserved.
dc.description.ia_keywordcancer, resistance, chemotherapeutic, radiotherapy, treatments, treatment, rosmarinic
dc.formatPDF
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5944
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceBiomolecules
dc.subject.ia_odsODS 12: Producción y consumo responsables
dc.subject.ia_oecd1nCiencias Médicas y de la Salud
dc.subject.ia_oecd2nMedicina Clínica
dc.subject.ia_oecd3nMedicina Clínica
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2024
oaire.citationIssue7
oaire.citationTitleBiomolecules
oaire.citationVolume14
oaire.fundingReferenceANID FONDECYT 1220831
oaire.fundingReferenceUniversidad de La Frontera APC
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo de revisión
oaire.resourceType.enReview
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Biológicas y Químicas
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionSCOPUS
uct.indizacionWOS
uct.indizacionDOAJ
uct.indizacionPubMed
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