Nanocellulose/Nanoporous Silicon Composite Films as a Drug Delivery System
Date
Authors
PESENTI PEREZ, HECTOR GONZALO
HERNANDEZ MONTELONGO, JESUS JACOBO
Garrido-Miranda, Karla A.
Pesenti, Héctor
Contreras, Ángel
Vergara-Figueroa, Judith
Recio-Sánchez, Gonzalo
Chumpitaz, Dalton Antonio
Ponce, Silvia
Hernández-Montelongo, Jacobo
HERNANDEZ MONTELONGO, JESUS JACOBO
Garrido-Miranda, Karla A.
Pesenti, Héctor
Contreras, Ángel
Vergara-Figueroa, Judith
Recio-Sánchez, Gonzalo
Chumpitaz, Dalton Antonio
Ponce, Silvia
Hernández-Montelongo, Jacobo
Authors
Date
Datos de publicación:
10.3390/polym16142055
Keywords
Composite Material - Drug Delivery System - Nanocellulose - Nanoporous Silicon - Aromatic Compounds - Biocompatibility - Biodegradability - Cellulose Films - Controlled Drug Delivery - Dyes - Escherichia Coli - Fourier Transform Infrared Spectroscopy - Nanocellulose - Nanocomposite Films - Nanocomposites - Physicochemical Properties - Porous Silicon - Targeted Drug Delivery - Thermogravimetric Analysis - Ultraviolet Visible Spectroscopy - Composites Material - Drug-delivery Systems - High Surface Area - Hydrogel Membrane - Methylene Blue - Micro Particles - Nano-cellulose - Nano-porous Silicon - Nanocellulose Films - Volume Ratio - Scanning Electron Microscopy
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Abstract
Nanocellulose (NC) is a promising material for drug delivery due to its high surface area-to-volume ratio, biocompatibility, biodegradability, and versatility in various formats (nanoparticles, hydrogels, microspheres, membranes, and films). In this study, nanocellulose films were derived from Bolaina blanca (Guazuma crinita) and combined with nanoporous silicon microparticles (nPSi) in concentrations ranging from 0.1% to 1.0% (w/v), using polyvinyl alcohol (PVA) as a binding agent to create NC/nPSi composite films for drug delivery systems. The physicochemical properties of the samples were characterized using UV-Vis spectroscopy, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy attenuated total reflectance (FTIR ATR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The mechanical properties and drug release capabilities were also evaluated using methylene blue (MB) as an antibacterial drug model. Antibacterial assays were conducted against S. aureus and E. coli bacteria. The results show that NC/nPSi composites with 1% nPSi increased the T<inf>50%</inf> by 10 °C and enhanced mechanical properties, such as a 70% increase in the elastic modulus and a 372% increase in elongation, compared to NC films. Additionally, MB released from NC/nPSi composites effectively inhibited the growth of both bacteria. It was also observed that the diffusion coefficients were inversely proportional to the % nPSi. These findings suggest that this novel NC/nPSi-based material can serve as an effective controlled drug release system. © 2024 Elsevier B.V., All rights reserved.
Description
Keywords
Composite Material , Drug Delivery System , Nanocellulose , Nanoporous Silicon , Aromatic Compounds , Biocompatibility , Biodegradability , Cellulose Films , Controlled Drug Delivery , Dyes , Escherichia Coli , Fourier Transform Infrared Spectroscopy , Nanocellulose , Nanocomposite Films , Nanocomposites , Physicochemical Properties , Porous Silicon , Targeted Drug Delivery , Thermogravimetric Analysis , Ultraviolet Visible Spectroscopy , Composites Material , Drug-delivery Systems , High Surface Area , Hydrogel Membrane , Methylene Blue , Micro Particles , Nano-cellulose , Nano-porous Silicon , Nanocellulose Films , Volume Ratio , Scanning Electron Microscopy
Citation
10.3390/polym16142055