Nanocellulose/Nanoporous Silicon Composite Films as a Drug Delivery System

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datacite.alternateIdentifier.citationPolymers, 16 (14), 2024
datacite.alternateIdentifier.doi10.3390/polym16142055
datacite.alternateIdentifier.issn2073-4360
datacite.creatorGarrido-Miranda, Karla A.
datacite.creatorPesenti, Héctor
datacite.creatorContreras, Ángel
datacite.creatorVergara-Figueroa, Judith
datacite.creatorRecio-Sánchez, Gonzalo
datacite.creatorChumpitaz, Dalton Antonio
datacite.creatorPonce, Silvia
datacite.creatorHernández-Montelongo, Jacobo
datacite.date2024
datacite.rightsAcceso abierto
datacite.subjectComposite Material
datacite.subjectDrug Delivery System
datacite.subjectNanocellulose
datacite.subjectNanoporous Silicon
datacite.subjectAromatic Compounds
datacite.subjectBiocompatibility
datacite.subjectBiodegradability
datacite.subjectCellulose Films
datacite.subjectControlled Drug Delivery
datacite.subjectDyes
datacite.subjectEscherichia Coli
datacite.subjectFourier Transform Infrared Spectroscopy
datacite.subjectNanocellulose
datacite.subjectNanocomposite Films
datacite.subjectNanocomposites
datacite.subjectPhysicochemical Properties
datacite.subjectPorous Silicon
datacite.subjectTargeted Drug Delivery
datacite.subjectThermogravimetric Analysis
datacite.subjectUltraviolet Visible Spectroscopy
datacite.subjectComposites Material
datacite.subjectDrug-delivery Systems
datacite.subjectHigh Surface Area
datacite.subjectHydrogel Membrane
datacite.subjectMethylene Blue
datacite.subjectMicro Particles
datacite.subjectNano-cellulose
datacite.subjectNano-porous Silicon
datacite.subjectNanocellulose Films
datacite.subjectVolume Ratio
datacite.subjectScanning Electron Microscopy
datacite.titleNanocellulose/Nanoporous Silicon Composite Films as a Drug Delivery System
dc.contributor.authorPESENTI PEREZ, HECTOR GONZALO
dc.contributor.authorHERNANDEZ MONTELONGO, JESUS JACOBO
dc.description.abstractNanocellulose (NC) is a promising material for drug delivery due to its high surface area-to-volume ratio, biocompatibility, biodegradability, and versatility in various formats (nanoparticles, hydrogels, microspheres, membranes, and films). In this study, nanocellulose films were derived from Bolaina blanca (Guazuma crinita) and combined with nanoporous silicon microparticles (nPSi) in concentrations ranging from 0.1% to 1.0% (w/v), using polyvinyl alcohol (PVA) as a binding agent to create NC/nPSi composite films for drug delivery systems. The physicochemical properties of the samples were characterized using UV-Vis spectroscopy, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy attenuated total reflectance (FTIR ATR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The mechanical properties and drug release capabilities were also evaluated using methylene blue (MB) as an antibacterial drug model. Antibacterial assays were conducted against S. aureus and E. coli bacteria. The results show that NC/nPSi composites with 1% nPSi increased the T<inf>50%</inf> by 10 °C and enhanced mechanical properties, such as a 70% increase in the elastic modulus and a 372% increase in elongation, compared to NC films. Additionally, MB released from NC/nPSi composites effectively inhibited the growth of both bacteria. It was also observed that the diffusion coefficients were inversely proportional to the % nPSi. These findings suggest that this novel NC/nPSi-based material can serve as an effective controlled drug release system. © 2024 Elsevier B.V., All rights reserved.
dc.description.ia_keywordnpsi, drug, films, were, nanocellulose, delivery, properties
dc.formatPDF
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5943
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourcePolymers
dc.subject.ia_oecd1nIngeniería y Tecnología
dc.subject.ia_oecd2nMateriales
dc.subject.ia_oecd3nCiencia de los Materiales
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2024
oaire.citationIssue14
oaire.citationTitlePolymers
oaire.citationVolume16
oaire.fundingReferenceANID FONDECYT 1230553 (Regular), 3220459 (Postdoctorado)
oaire.fundingReferenceBIOREN UFRO SmartC-BIOREN CCSS210005
oaire.fundingReferenceCONCYTEC-PROCIENCIA (E063-2020-01-BM-74448, 009-2020)
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
relation.isAuthorOfPublication06eb1649-f51e-4f5e-ade8-49a1aca6c98e
relation.isAuthorOfPublicationd1ebb975-fdac-4b8f-9131-a735b8c04d80
relation.isAuthorOfPublication.latestForDiscovery06eb1649-f51e-4f5e-ade8-49a1aca6c98e
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Biológicas y Químicas
uct.departamentoDepartamento de Bioingeniería Traslacional
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed Central (PMC)
uct.indizacionChemical Abstracts Service (CAS)
uct.indizacionEi Compendex
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