The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?
Date
Authors
ORTLOFF TRAUTMANN, ALEXANDER
Bustamante-Barrientos, Felipe A.
Méndez-Ruette, Maxs
Ortloff, Alexander R.
Luz-Crawford, Patricia A.
Rivera, Francisco J.
Figueroa, Carlos D.
Molina, Luis
Bátiz, Luis Federico
Bustamante-Barrientos, Felipe A.
Méndez-Ruette, Maxs
Ortloff, Alexander R.
Luz-Crawford, Patricia A.
Rivera, Francisco J.
Figueroa, Carlos D.
Molina, Luis
Bátiz, Luis Federico
Authors
Date
Datos de publicación:
10.3389/fncel.2021.636176
Keywords
17?-estradiol - Alzheimer s Disease - Bisphenol A - Er?/? - Gper1/gpr30 - Hormone Replacement Therapy - Neural Stem/progenitor Cells - Parkinson s Disease - 4,4' Isopropylidenediphenol - Androstenedione - Brain Derived Neurotrophic Factor - Catalase - Curcumin - Dna (apurinic Or Apyrimidinic Site) Lyase - Doublecortin - Endoxifen - Epidermal Growth Factor Receptor - Estradiol - Genistein - Growth Hormone - Isoflavone - Levodopa - Neuropeptide Y - Nitric Oxide - Protein Kinase B - Raloxifene - Resveratrol - Somatomedin C - Superoxide Dismutase - Tamoxifen - Testosterone - 4,4' Isopropylidenediphenol - Androstenedione - Antioxidant - Brain Derived Neurotrophic Factor - Catalase - Contraceptive Agent - Curcumin - Diarylpropionitrile - Dna (apurinic Or Apyrimidinic Site) Lyase - Doublecortin - Endocrine Disruptor - Endoxifen - Epidermal Growth Factor Receptor - Estradiol - Estrogen - Estrogen Receptor - Estrogen Receptor Alpha - Estrogen Receptor Beta - Extra Virgin Olive Oil - Flavonoid - G Protein Coupled Receptor 30 - Genistein - Growth Factor - Growth Hormone - Isoflavone - Levodopa - Mammalian Target Of Rapamycin - Microrna - Neuropeptide Y - Nitric Oxide - Phytoestrogen - Protein Bax - Protein Kinase B - Protein P53 - Raloxifene - Reactive Oxygen Metabolite - Resveratrol - Retinoblastoma Protein - Somatomedin C - Superoxide Dismutase - Tamoxifen - Testosterone - Tumor Necrosis Factor - Adult - Aging - Akt/mtor Signaling - Alzheimer Disease - Antibody Labeling - Antioxidant Activity - Apoptosis - Brain Blood Flow - Brain Development - Brain Ischemia - Breast Cancer - Cardiovascular Disease - Cell Differentiation - Cell Membrane - Cell Proliferation - Cell Survival - Cell Viability - Cerebrovascular Accident - Cognition - Corpus Callosum - Cytotoxicity - Degenerative Disease - Dna Repair - Dna Replication - Down Regulation - Endothelial Progenitor Cell - Gene Expression - Genomic Instability - Hormonal Contraception - Hormone Substitution - Human - Kinetosome - Mapk Signaling - Mesenchymal Stem Cell - Mitochondrial Biogenesis - Mitochondrial Membrane Potential - Nerve Cell Differentiation - Nerve Cell Plasticity - Nerve Degeneration - Nervous System Development - Neural Stem Cell - Neurite Outgrowth - Nonhuman - Oligodendroglia - Oxidative Stress - Parkinson Disease - Protein Expression - Quality Of Life - Review - Signal Transduction - Upregulation
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Abstract
Estrogens and estrogen-like molecules can modify the biology of several cell types. Estrogen receptors alpha (ER?) and beta (ER?) belong to the so-called classical family of estrogen receptors, while the G protein-coupled estrogen receptor 1 (GPER-1) represents a non-classical estrogen receptor mainly located in the plasma membrane. As estrogen receptors are ubiquitously distributed, they can modulate cell proliferation, differentiation, and survival in several tissues and organs, including the central nervous system (CNS). Estrogens can exert neuroprotective roles by acting as anti-oxidants, promoting DNA repair, inducing the expression of growth factors, and modulating cerebral blood flow. Additionally, estrogen-dependent signaling pathways are involved in regulating the balance between proliferation and differentiation of neural stem/progenitor cells (NSPCs), thus influencing neurogenic processes. Since several estrogen-based therapies are used nowadays and estrogen-like molecules, including phytoestrogens and xenoestrogens, are omnipresent in our environment, estrogen-dependent changes in cell biology and tissue homeostasis have gained attention in human health and disease. This article provides a comprehensive literature review on the current knowledge of estrogen and estrogen-like molecules and their impact on cell survival and neurodegeneration, as well as their role in NSPCs proliferation/differentiation balance and neurogenesis. © 2021 Elsevier B.V., All rights reserved.
Description
Keywords
17?-estradiol , Alzheimer s Disease , Bisphenol A , Er?/? , Gper1/gpr30 , Hormone Replacement Therapy , Neural Stem/progenitor Cells , Parkinson s Disease , 4,4' Isopropylidenediphenol , Androstenedione , Brain Derived Neurotrophic Factor , Catalase , Curcumin , Dna (apurinic Or Apyrimidinic Site) Lyase , Doublecortin , Endoxifen , Epidermal Growth Factor Receptor , Estradiol , Genistein , Growth Hormone , Isoflavone , Levodopa , Neuropeptide Y , Nitric Oxide , Protein Kinase B , Raloxifene , Resveratrol , Somatomedin C , Superoxide Dismutase , Tamoxifen , Testosterone , 4,4' Isopropylidenediphenol , Androstenedione , Antioxidant , Brain Derived Neurotrophic Factor , Catalase , Contraceptive Agent , Curcumin , Diarylpropionitrile , Dna (apurinic Or Apyrimidinic Site) Lyase , Doublecortin , Endocrine Disruptor , Endoxifen , Epidermal Growth Factor Receptor , Estradiol , Estrogen , Estrogen Receptor , Estrogen Receptor Alpha , Estrogen Receptor Beta , Extra Virgin Olive Oil , Flavonoid , G Protein Coupled Receptor 30 , Genistein , Growth Factor , Growth Hormone , Isoflavone , Levodopa , Mammalian Target Of Rapamycin , Microrna , Neuropeptide Y , Nitric Oxide , Phytoestrogen , Protein Bax , Protein Kinase B , Protein P53 , Raloxifene , Reactive Oxygen Metabolite , Resveratrol , Retinoblastoma Protein , Somatomedin C , Superoxide Dismutase , Tamoxifen , Testosterone , Tumor Necrosis Factor , Adult , Aging , Akt/mtor Signaling , Alzheimer Disease , Antibody Labeling , Antioxidant Activity , Apoptosis , Brain Blood Flow , Brain Development , Brain Ischemia , Breast Cancer , Cardiovascular Disease , Cell Differentiation , Cell Membrane , Cell Proliferation , Cell Survival , Cell Viability , Cerebrovascular Accident , Cognition , Corpus Callosum , Cytotoxicity , Degenerative Disease , Dna Repair , Dna Replication , Down Regulation , Endothelial Progenitor Cell , Gene Expression , Genomic Instability , Hormonal Contraception , Hormone Substitution , Human , Kinetosome , Mapk Signaling , Mesenchymal Stem Cell , Mitochondrial Biogenesis , Mitochondrial Membrane Potential , Nerve Cell Differentiation , Nerve Cell Plasticity , Nerve Degeneration , Nervous System Development , Neural Stem Cell , Neurite Outgrowth , Nonhuman , Oligodendroglia , Oxidative Stress , Parkinson Disease , Protein Expression , Quality Of Life , Review , Signal Transduction , Upregulation
Citation
10.3389/fncel.2021.636176