The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?

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datacite.alternateIdentifier.citationFrontiers in Cellular Neuroscience, 15, 2021
datacite.alternateIdentifier.doi10.3389/fncel.2021.636176
datacite.alternateIdentifier.issn1662-5102
datacite.creatorBustamante-Barrientos, Felipe A.
datacite.creatorMéndez-Ruette, Maxs
datacite.creatorOrtloff, Alexander R.
datacite.creatorLuz-Crawford, Patricia A.
datacite.creatorRivera, Francisco J.
datacite.creatorFigueroa, Carlos D.
datacite.creatorMolina, Luis
datacite.creatorBátiz, Luis Federico
datacite.date2021
datacite.rightsAcceso abierto
datacite.subject17?-estradiol
datacite.subjectAlzheimer s Disease
datacite.subjectBisphenol A
datacite.subjectEr?/?
datacite.subjectGper1/gpr30
datacite.subjectHormone Replacement Therapy
datacite.subjectNeural Stem/progenitor Cells
datacite.subjectParkinson s Disease
datacite.subject4,4' Isopropylidenediphenol
datacite.subjectAndrostenedione
datacite.subjectBrain Derived Neurotrophic Factor
datacite.subjectCatalase
datacite.subjectCurcumin
datacite.subjectDna (apurinic Or Apyrimidinic Site) Lyase
datacite.subjectDoublecortin
datacite.subjectEndoxifen
datacite.subjectEpidermal Growth Factor Receptor
datacite.subjectEstradiol
datacite.subjectGenistein
datacite.subjectGrowth Hormone
datacite.subjectIsoflavone
datacite.subjectLevodopa
datacite.subjectNeuropeptide Y
datacite.subjectNitric Oxide
datacite.subjectProtein Kinase B
datacite.subjectRaloxifene
datacite.subjectResveratrol
datacite.subjectSomatomedin C
datacite.subjectSuperoxide Dismutase
datacite.subjectTamoxifen
datacite.subjectTestosterone
datacite.subject4,4' Isopropylidenediphenol
datacite.subjectAndrostenedione
datacite.subjectAntioxidant
datacite.subjectBrain Derived Neurotrophic Factor
datacite.subjectCatalase
datacite.subjectContraceptive Agent
datacite.subjectCurcumin
datacite.subjectDiarylpropionitrile
datacite.subjectDna (apurinic Or Apyrimidinic Site) Lyase
datacite.subjectDoublecortin
datacite.subjectEndocrine Disruptor
datacite.subjectEndoxifen
datacite.subjectEpidermal Growth Factor Receptor
datacite.subjectEstradiol
datacite.subjectEstrogen
datacite.subjectEstrogen Receptor
datacite.subjectEstrogen Receptor Alpha
datacite.subjectEstrogen Receptor Beta
datacite.subjectExtra Virgin Olive Oil
datacite.subjectFlavonoid
datacite.subjectG Protein Coupled Receptor 30
datacite.subjectGenistein
datacite.subjectGrowth Factor
datacite.subjectGrowth Hormone
datacite.subjectIsoflavone
datacite.subjectLevodopa
datacite.subjectMammalian Target Of Rapamycin
datacite.subjectMicrorna
datacite.subjectNeuropeptide Y
datacite.subjectNitric Oxide
datacite.subjectPhytoestrogen
datacite.subjectProtein Bax
datacite.subjectProtein Kinase B
datacite.subjectProtein P53
datacite.subjectRaloxifene
datacite.subjectReactive Oxygen Metabolite
datacite.subjectResveratrol
datacite.subjectRetinoblastoma Protein
datacite.subjectSomatomedin C
datacite.subjectSuperoxide Dismutase
datacite.subjectTamoxifen
datacite.subjectTestosterone
datacite.subjectTumor Necrosis Factor
datacite.subjectAdult
datacite.subjectAging
datacite.subjectAkt/mtor Signaling
datacite.subjectAlzheimer Disease
datacite.subjectAntibody Labeling
datacite.subjectAntioxidant Activity
datacite.subjectApoptosis
datacite.subjectBrain Blood Flow
datacite.subjectBrain Development
datacite.subjectBrain Ischemia
datacite.subjectBreast Cancer
datacite.subjectCardiovascular Disease
datacite.subjectCell Differentiation
datacite.subjectCell Membrane
datacite.subjectCell Proliferation
datacite.subjectCell Survival
datacite.subjectCell Viability
datacite.subjectCerebrovascular Accident
datacite.subjectCognition
datacite.subjectCorpus Callosum
datacite.subjectCytotoxicity
datacite.subjectDegenerative Disease
datacite.subjectDna Repair
datacite.subjectDna Replication
datacite.subjectDown Regulation
datacite.subjectEndothelial Progenitor Cell
datacite.subjectGene Expression
datacite.subjectGenomic Instability
datacite.subjectHormonal Contraception
datacite.subjectHormone Substitution
datacite.subjectHuman
datacite.subjectKinetosome
datacite.subjectMapk Signaling
datacite.subjectMesenchymal Stem Cell
datacite.subjectMitochondrial Biogenesis
datacite.subjectMitochondrial Membrane Potential
datacite.subjectNerve Cell Differentiation
datacite.subjectNerve Cell Plasticity
datacite.subjectNerve Degeneration
datacite.subjectNervous System Development
datacite.subjectNeural Stem Cell
datacite.subjectNeurite Outgrowth
datacite.subjectNonhuman
datacite.subjectOligodendroglia
datacite.subjectOxidative Stress
datacite.subjectParkinson Disease
datacite.subjectProtein Expression
datacite.subjectQuality Of Life
datacite.subjectReview
datacite.subjectSignal Transduction
datacite.subjectUpregulation
datacite.titleThe Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?
dc.contributor.authorORTLOFF TRAUTMANN, ALEXANDER
dc.description.abstractEstrogens and estrogen-like molecules can modify the biology of several cell types. Estrogen receptors alpha (ER?) and beta (ER?) belong to the so-called classical family of estrogen receptors, while the G protein-coupled estrogen receptor 1 (GPER-1) represents a non-classical estrogen receptor mainly located in the plasma membrane. As estrogen receptors are ubiquitously distributed, they can modulate cell proliferation, differentiation, and survival in several tissues and organs, including the central nervous system (CNS). Estrogens can exert neuroprotective roles by acting as anti-oxidants, promoting DNA repair, inducing the expression of growth factors, and modulating cerebral blood flow. Additionally, estrogen-dependent signaling pathways are involved in regulating the balance between proliferation and differentiation of neural stem/progenitor cells (NSPCs), thus influencing neurogenic processes. Since several estrogen-based therapies are used nowadays and estrogen-like molecules, including phytoestrogens and xenoestrogens, are omnipresent in our environment, estrogen-dependent changes in cell biology and tissue homeostasis have gained attention in human health and disease. This article provides a comprehensive literature review on the current knowledge of estrogen and estrogen-like molecules and their impact on cell survival and neurodegeneration, as well as their role in NSPCs proliferation/differentiation balance and neurogenesis. © 2021 Elsevier B.V., All rights reserved.
dc.description.ia_keywordestrogen, like, molecules, cell, several, receptors, proliferation
dc.formatPDF
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/4387
dc.language.isoen
dc.publisherFrontiers Media
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceFrontiers in Cellular Neuroscience
dc.subject.ia_odsODS 3: Salud y bienestar
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Biológicas
dc.subject.ia_oecd3nBiología General
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2021
oaire.citationTitleFrontiers in Cellular Neuroscience
oaire.citationVolume15
oaire.fundingReferenceANID FONDECYT 1141015, 1211384, 1161787, 1201706 (Regulares)
oaire.fundingReferenceANID COVID0706
oaire.fundingReferenceCONICYT Doctorado Nacional 21130902, 21160084
oaire.fundingReferenceUniversidad San Sebastián VRIDFAPPE20/01
oaire.fundingReferenceUANDES FAI PhD Scholarship
oaire.fundingReferenceUANDES Postdoctoral Fellowship
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo de revisión
oaire.resourceType.enReview
relation.isAuthorOfPublication798755f1-1bb9-449a-b2e2-d4bbe38ca016
relation.isAuthorOfPublication.latestForDiscovery798755f1-1bb9-449a-b2e2-d4bbe38ca016
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Veterinarias y Salud Pública
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionSCOPUS
uct.indizacionWOS
uct.indizacionDOAJ
uct.indizacionPubMed
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