Use of nPSi-beta CD Composite Microparticles for the Controlled Release of Caffeic Acid and Pinocembrin, Two Main Polyphenolic Compounds Found in a Chilean Propolis

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datacite.alternateIdentifier.citationPHARMACEUTICS,Vol.11,,2019
datacite.alternateIdentifier.doi10.3390/pharmaceutics11060289
datacite.creatorGuzman Oyarzo, Dina
datacite.creatorPlaza, Tanya
datacite.creatorRecio Sánchez, Gonzalo
datacite.creatorAbdalla, Dulcineia S. P.
datacite.creatorSalazar, Luis A.
datacite.creatorHernandez Montelongo, Jacobo
datacite.date2019
datacite.subject.englishcontrolled release
datacite.subject.englishnanoporous silicon
datacite.subject.englishbeta CD polymer
datacite.subject.englishcaffeic acid
datacite.subject.englishpinocembrin
datacite.subject.englishpolyphenols
datacite.subject.englishHUVECs
datacite.titleUse of nPSi-beta CD Composite Microparticles for the Controlled Release of Caffeic Acid and Pinocembrin, Two Main Polyphenolic Compounds Found in a Chilean Propolis
dc.date.accessioned2021-04-30T16:46:58Z
dc.date.available2021-04-30T16:46:58Z
dc.description.abstractPropolis is widely recognized for its various therapeutic properties. These are attributed to its rich composition in polyphenols, which exhibit multiple biological properties (e.g., antioxidant, anti-inflammatory, anti-angiogenic). Despite its multiple benefits, oral administration of polyphenols results in low bioavailability at the action site. An alternative to face this problem is the use of biomaterials at nano-micro scale due to its high versatility as carriers and delivery systems of various drugs and biomolecules. The aim of this work is to determine if nPSi-beta CD microparticles are a suitable material for the load and controlled release of caffeic acid (CA) and pinocembrin (Pin), two of the main components of a Chilean propolis with anti-atherogenic and anti-angiogenic activity. Polyphenols and nPSi-beta CD microparticles cytocompatibility studies were carried out with human umbilical vein endothelial cells (HUVECs). Results from physicochemical characterization demonstrated nPSi-beta CD microparticles successfully retained and controlled release CA and Pin. Furthermore, nPSi-beta CD microparticles presented cytocompatibility with HUVECs culture at concentrations of 0.25 mg/mL. These results suggest that nPSi-beta CD microparticles could safely be used as an alternate oral delivery system to improve controlled release and bioavailability of CA or Pin-and eventually other polyphenols-thus enhancing its therapeutic effect for the treatment of different diseases.
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3439
dc.language.isoen
dc.publisherMDPI
dc.sourcePHARMACEUTICS
oaire.resourceTypeArticle
uct.catalogadorWOS
uct.indizacionSCI
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