Use of nPSi-beta CD Composite Microparticles for the Controlled Release of Caffeic Acid and Pinocembrin, Two Main Polyphenolic Compounds Found in a Chilean Propolis

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dc.contributor.authorGuzman Oyarzo, Dina
dc.contributor.authorPlaza, Tanya
dc.contributor.authorRecio Sánchez, Gonzalo
dc.contributor.authorAbdalla, Dulcineia S. P.
dc.contributor.authorSalazar, Luis A.
dc.contributor.authorHernandez Montelongo, Jacobo
dc.date2019
dc.date.accessioned2021-04-30T16:46:58Z
dc.date.available2021-04-30T16:46:58Z
dc.description.abstractPropolis is widely recognized for its various therapeutic properties. These are attributed to its rich composition in polyphenols, which exhibit multiple biological properties (e.g., antioxidant, anti-inflammatory, anti-angiogenic). Despite its multiple benefits, oral administration of polyphenols results in low bioavailability at the action site. An alternative to face this problem is the use of biomaterials at nano-micro scale due to its high versatility as carriers and delivery systems of various drugs and biomolecules. The aim of this work is to determine if nPSi-beta CD microparticles are a suitable material for the load and controlled release of caffeic acid (CA) and pinocembrin (Pin), two of the main components of a Chilean propolis with anti-atherogenic and anti-angiogenic activity. Polyphenols and nPSi-beta CD microparticles cytocompatibility studies were carried out with human umbilical vein endothelial cells (HUVECs). Results from physicochemical characterization demonstrated nPSi-beta CD microparticles successfully retained and controlled release CA and Pin. Furthermore, nPSi-beta CD microparticles presented cytocompatibility with HUVECs culture at concentrations of 0.25 mg/mL. These results suggest that nPSi-beta CD microparticles could safely be used as an alternate oral delivery system to improve controlled release and bioavailability of CA or Pin-and eventually other polyphenols-thus enhancing its therapeutic effect for the treatment of different diseases.
dc.identifier.citationPHARMACEUTICS,Vol.11,,2019
dc.identifier.doi10.3390/pharmaceutics11060289
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3439
dc.language.isoen
dc.publisherMDPI
dc.sourcePHARMACEUTICS
dc.subject.englishcontrolled release
dc.subject.englishnanoporous silicon
dc.subject.englishbeta CD polymer
dc.subject.englishcaffeic acid
dc.subject.englishpinocembrin
dc.subject.englishpolyphenols
dc.subject.englishHUVECs
dc.titleUse of nPSi-beta CD Composite Microparticles for the Controlled Release of Caffeic Acid and Pinocembrin, Two Main Polyphenolic Compounds Found in a Chilean Propolis
dc.typeArticle
uct.catalogadorWOS
uct.indizacionSCI
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