Use of npsi-βcd composite microparticles for the controlled release of caffeic acid and pinocembrin, two main polyphenolic compounds found in a chilean propolis
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Authors
HERNANDEZ MONTELONGO, JESUS JACOBO
Guzmán-Oyarzo, Dina
Plaza, Tanya
Recio-Sánchez, Gonzalo
Abdalla, Dulcinéia Saes Parra
Salazar Navarrete, Luis A.
Hernández-Montelongo, Jacobo
Guzmán-Oyarzo, Dina
Plaza, Tanya
Recio-Sánchez, Gonzalo
Abdalla, Dulcinéia Saes Parra
Salazar Navarrete, Luis A.
Hernández-Montelongo, Jacobo
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Date
Datos de publicación:
10.3390/pharmaceutics11060289
Keywords
Caffeic Acid - Controlled Release - Huvecs - Nanoporous Silicon - Pinocembrin - Polyphenols - ?cd Polymer - Beta Cyclodextrin - Caffeic Acid - Pinocembrine - Silicone - Beta Cyclodextrin - Caffeic Acid - Nanoparticle - Nanoporous Silicone - Pinocembrine - Silicone - Unclassified Drug - Antiangiogenic Activity - Antiatherogenic Activity - Article - Chilean Propolis - Concentration Response - Controlled Release Formulation - Controlled Study - Drug Activity - Drug Cytotoxicity - Drug Delivery System - Human - Human Cell - Huvec Cell Line - Hydrophobicity - In Vitro Study - Medicinal Plant - Membrane Microparticle - Physical Chemistry
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Abstract
Propolis is widely recognized for its various therapeutic properties. These are attributed to its rich composition in polyphenols, which exhibit multiple biological properties (e.g., antioxidant, anti-inflammatory, anti-angiogenic). Despite its multiple benefits, oral administration of polyphenols results in low bioavailability at the action site. An alternative to face this problem is the use of biomaterials at nano-micro scale due to its high versatility as carriers and delivery systems of various drugs and biomolecules. The aim of this work is to determine if nPSi-?CD microparticles are a suitable material for the load and controlled release of caffeic acid (CA) and pinocembrin (Pin), two of the main components of a Chilean propolis with anti-atherogenic and anti-angiogenic activity. Polyphenols and nPSi-?CD microparticles cytocompatibility studies were carried out with human umbilical vein endothelial cells (HUVECs). Results from physicochemical characterization demonstrated nPSi-?CD microparticles successfully retained and controlled release CA and Pin. Furthermore, nPSi-?CD microparticles presented cytocompatibility with HUVECs culture at concentrations of 0.25 mg/mL. These results suggest that nPSi-?CD microparticles could safely be used as an alternate oral delivery system to improve controlled release and bioavailability of CA or Pin and eventually other polyphenols thus enhancing its therapeutic effect for the treatment of different diseases. © 2019 Elsevier B.V., All rights reserved.
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Keywords
Caffeic Acid , Controlled Release , Huvecs , Nanoporous Silicon , Pinocembrin , Polyphenols , ?cd Polymer , Beta Cyclodextrin , Caffeic Acid , Pinocembrine , Silicone , Beta Cyclodextrin , Caffeic Acid , Nanoparticle , Nanoporous Silicone , Pinocembrine , Silicone , Unclassified Drug , Antiangiogenic Activity , Antiatherogenic Activity , Article , Chilean Propolis , Concentration Response , Controlled Release Formulation , Controlled Study , Drug Activity , Drug Cytotoxicity , Drug Delivery System , Human , Human Cell , Huvec Cell Line , Hydrophobicity , In Vitro Study , Medicinal Plant , Membrane Microparticle , Physical Chemistry
Citation
10.3390/pharmaceutics11060289