Use of npsi-βcd composite microparticles for the controlled release of caffeic acid and pinocembrin, two main polyphenolic compounds found in a chilean propolis

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datacite.alternateIdentifier.citationPharmaceutics, 11 (6), 2019
datacite.alternateIdentifier.doi10.3390/pharmaceutics11060289
datacite.alternateIdentifier.issn1999-4923
datacite.creatorGuzmán-Oyarzo, Dina
datacite.creatorPlaza, Tanya
datacite.creatorRecio-Sánchez, Gonzalo
datacite.creatorAbdalla, Dulcinéia Saes Parra
datacite.creatorSalazar Navarrete, Luis A.
datacite.creatorHernández-Montelongo, Jacobo
datacite.date2019
datacite.rightsAcceso abierto
datacite.subjectCaffeic Acid
datacite.subjectControlled Release
datacite.subjectHuvecs
datacite.subjectNanoporous Silicon
datacite.subjectPinocembrin
datacite.subjectPolyphenols
datacite.subject?cd Polymer
datacite.subjectBeta Cyclodextrin
datacite.subjectCaffeic Acid
datacite.subjectPinocembrine
datacite.subjectSilicone
datacite.subjectBeta Cyclodextrin
datacite.subjectCaffeic Acid
datacite.subjectNanoparticle
datacite.subjectNanoporous Silicone
datacite.subjectPinocembrine
datacite.subjectSilicone
datacite.subjectUnclassified Drug
datacite.subjectAntiangiogenic Activity
datacite.subjectAntiatherogenic Activity
datacite.subjectArticle
datacite.subjectChilean Propolis
datacite.subjectConcentration Response
datacite.subjectControlled Release Formulation
datacite.subjectControlled Study
datacite.subjectDrug Activity
datacite.subjectDrug Cytotoxicity
datacite.subjectDrug Delivery System
datacite.subjectHuman
datacite.subjectHuman Cell
datacite.subjectHuvec Cell Line
datacite.subjectHydrophobicity
datacite.subjectIn Vitro Study
datacite.subjectMedicinal Plant
datacite.subjectMembrane Microparticle
datacite.subjectPhysical Chemistry
datacite.titleUse of npsi-βcd composite microparticles for the controlled release of caffeic acid and pinocembrin, two main polyphenolic compounds found in a chilean propolis
dc.contributor.authorHERNANDEZ MONTELONGO, JESUS JACOBO
dc.description.abstractPropolis is widely recognized for its various therapeutic properties. These are attributed to its rich composition in polyphenols, which exhibit multiple biological properties (e.g., antioxidant, anti-inflammatory, anti-angiogenic). Despite its multiple benefits, oral administration of polyphenols results in low bioavailability at the action site. An alternative to face this problem is the use of biomaterials at nano-micro scale due to its high versatility as carriers and delivery systems of various drugs and biomolecules. The aim of this work is to determine if nPSi-?CD microparticles are a suitable material for the load and controlled release of caffeic acid (CA) and pinocembrin (Pin), two of the main components of a Chilean propolis with anti-atherogenic and anti-angiogenic activity. Polyphenols and nPSi-?CD microparticles cytocompatibility studies were carried out with human umbilical vein endothelial cells (HUVECs). Results from physicochemical characterization demonstrated nPSi-?CD microparticles successfully retained and controlled release CA and Pin. Furthermore, nPSi-?CD microparticles presented cytocompatibility with HUVECs culture at concentrations of 0.25 mg/mL. These results suggest that nPSi-?CD microparticles could safely be used as an alternate oral delivery system to improve controlled release and bioavailability of CA or Pin and eventually other polyphenols thus enhancing its therapeutic effect for the treatment of different diseases. © 2019 Elsevier B.V., All rights reserved.
dc.description.ia_keywordnpsi, microparticles, polyphenols, anti, controlled, release, propolis
dc.formatPDF
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/3439
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourcePharmaceutics
dc.subject.ia_odsODS 8: Trabajo decente y crecimiento económico
dc.subject.ia_oecd1nIngeniería y Tecnología
dc.subject.ia_oecd2nMateriales
dc.subject.ia_oecd3nCiencia de los Materiales
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2019
oaire.citationIssue6
oaire.citationTitlePharmaceutics
oaire.citationVolume11
oaire.fundingReferenceANID FONDECYT 11180395 (Iniciación), 1171765 (Regular)
oaire.fundingReferenceCONICYT Beca Doctorado 21140154
oaire.fundingReferenceUCT F2017-PFJH-07
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
relation.isAuthorOfPublicationd1ebb975-fdac-4b8f-9131-a735b8c04d80
relation.isAuthorOfPublication.latestForDiscoveryd1ebb975-fdac-4b8f-9131-a735b8c04d80
uct.catalogadorjvu
uct.comunidadIngenieríaen_US
uct.departamentoDepartamento de Ciencias Matemáticas y Físicas
uct.facultadFacultad de Ingeniería
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed Central (PMC)
uct.indizacionEmbase
uct.indizacionChemical Abstracts Service (CAS)
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