Controlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-beta CD Composites Improves Their Antiangiogenic Activity

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datacite.alternateIdentifier.citationPHARMACEUTICS,Vol.14,,2022
datacite.alternateIdentifier.doi10.3390/pharmaceutics14030484
datacite.creatorGuzman Oyarzo, Dina
datacite.creatorHernandez Montelongo, Jacobo
datacite.creatorRosas, Carlos
datacite.creatorLeal, Pamela
datacite.creatorWeber, Helga
datacite.creatorAlvear, Marysol
datacite.creatorSalazar, Luis A.
datacite.date2022
datacite.subject.englishantiangiogenic activity
datacite.subject.englishcaffeic acid
datacite.subject.englishpinocembrin
datacite.subject.englishpolyphenols
datacite.subject.englishHUVECs
datacite.subject.englishcontrolled release
datacite.subject.englishnPSi/beta CD microparticle
datacite.titleControlled Release of Caffeic Acid and Pinocembrin by Use of nPSi-beta CD Composites Improves Their Antiangiogenic Activity
dc.date.accessioned2022-04-18T17:05:49Z
dc.date.available2022-04-18T17:05:49Z
dc.description.abstractAlthough polyphenols have great pharmacological potential, the main disadvantage is that they have low bioavailability at the desired site. Thus, the use of biocompatible systems for drug delivery is a strategy that is currently gaining great interest. The objective of this study is to evaluate the effect of microencapsulation of caffeic acid and pinocembrin on the antioxidant and antiangiogenic activity of both polyphenols, by the use of nPSi-beta CD composite microparticles. For this HUVEC, cells were exposed to H2O2 and to treatments with polyphenols in solution and loaded in the composite microparticle. The polyphenols were incorporated into a microparticle using nanoporous silicon, chitosan and a beta-cyclodextrin polymer as the biomaterial. The evaluation of the antiangiogenic effect of the treatments with polyphenols in solution and microencapsulated was carried out through functional tests, and the changes in the expression of target genes associated with the antioxidant pathway and angiogenesis was performed through qPCR. The results obtained show that the caffeic acid and pinocembrin have an antioxidant and antiangiogenic activity, both in solution as microencapsulated. In the caffeic acid, a greater biological effect was observed when it was incorporated into the nPSi-beta CD composite microparticle. Our results suggest that the nPSi-beta CD composite microparticle could be used as an alternative oral drug administration system.
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/4540
dc.language.isoen
dc.publisherMDPI
dc.sourcePHARMACEUTICS
oaire.resourceTypeArticle
uct.indizacionSCI
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