The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment

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datacite.alternateIdentifier.citationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,Vol.24,2023
datacite.alternateIdentifier.doi10.3390/ijms241310737
datacite.creatorMarin, Victor
datacite.creatorBurgos, Viviana
datacite.creatorPerez, Rebeca
datacite.creatorMaria, Durvanei Augusto
datacite.creatorPardi, Paulo
datacite.creatorPaz, Cristian
datacite.date2023
datacite.subject.englishepigallocatechin-3-gallate
datacite.subject.englishbreast cancer
datacite.subject.englishsynergistic chemotherapy
datacite.subject.englishmetabolism
datacite.subject.englishdrug delivery
datacite.titleThe Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment
dc.date.accessioned2024-05-27T18:26:07Z
dc.date.available2024-05-27T18:26:07Z
dc.description.abstractBreast cancer is one of the most diagnosed cancers worldwide, with an incidence of 47.8%. Its treatment includes surgery, radiotherapy, chemotherapy, and antibodies giving a mortality of 13.6%. Breast tumor development is driven by a variety of signaling pathways with high heterogeneity of surface receptors, which makes treatment difficult. Epigallocatechin-3-gallate (EGCG) is a natural polyphenol isolated as the main component in green tea; it has shown multiple beneficial effects in breast cancer, controlling proliferation, invasion, apoptosis, inflammation, and demethylation of DNA. These properties were proved in vitro and in vivo together with synergistic effects in combination with traditional chemotherapy, increasing the effectiveness of the treatment. This review focuses on the effects of EGCG on the functional capabilities acquired by breast tumor cells during its multistep development, the molecular and signal pathways involved, the synergistic effects in combination with current drugs, and how nanomaterials can improve its bioavailability on breast cancer treatment.
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5692
dc.language.isoen
dc.publisherMDPI
dc.sourceINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
oaire.resourceTypeReview
uct.indizacionSCI
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