The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment
The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment
Authors
Marin, Victor
Burgos, Viviana
Perez, Rebeca
Maria, Durvanei Augusto
Pardi, Paulo
Paz, Cristian
Burgos, Viviana
Perez, Rebeca
Maria, Durvanei Augusto
Pardi, Paulo
Paz, Cristian
Profesor GuĆa
Authors
Date
Datos de publicaciĆ³n:
10.3390/ijms241310737
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,Vol.24,2023
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,Vol.24,2023
Tipo de recurso
Review
Keywords
Materia geogrƔfica
Collections
Abstract
Breast cancer is one of the most diagnosed cancers worldwide, with an incidence of 47.8%. Its treatment includes surgery, radiotherapy, chemotherapy, and antibodies giving a mortality of 13.6%. Breast tumor development is driven by a variety of signaling pathways with high heterogeneity of surface receptors, which makes treatment difficult. Epigallocatechin-3-gallate (EGCG) is a natural polyphenol isolated as the main component in green tea; it has shown multiple beneficial effects in breast cancer, controlling proliferation, invasion, apoptosis, inflammation, and demethylation of DNA. These properties were proved in vitro and in vivo together with synergistic effects in combination with traditional chemotherapy, increasing the effectiveness of the treatment. This review focuses on the effects of EGCG on the functional capabilities acquired by breast tumor cells during its multistep development, the molecular and signal pathways involved, the synergistic effects in combination with current drugs, and how nanomaterials can improve its bioavailability on breast cancer treatment.