Antibacterial Films of Silver Nanoparticles Embedded into Carboxymethylcellulose/Chitosan Multilayers on Nanoporous Silicon: A Layer-by-Layer Assembly Approach Comparing Dip and Spin Coating

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datacite.alternateIdentifier.citationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,Vol.24,2023
datacite.alternateIdentifier.doi10.3390/ijms241310595
datacite.creatorNaveas, Nelson
datacite.creatorPulido, Ruth
datacite.creatorTorres-Costa, Vicente
datacite.creatorAgullo-Rueda, Fernando
datacite.creatorSantibanez, Mauricio
datacite.creatorMalano, Francisco
datacite.creatorRecio-Sanchez, Gonzalo
datacite.creatorGarrido-Miranda, Karla A.
datacite.creatorManso-Silvan, Miguel
datacite.creatorHernandez-Montelongo, Jacobo
datacite.date2023
datacite.subject.englishantibacterial films
datacite.subject.englishcarboxymethylcellulose
datacite.subject.englishchitosan
datacite.subject.englishsilver nanoparticles
datacite.subject.englishnanoporous silicon
datacite.subject.englishcomposite material
datacite.subject.englishlayer-by-layer
datacite.titleAntibacterial Films of Silver Nanoparticles Embedded into Carboxymethylcellulose/Chitosan Multilayers on Nanoporous Silicon: A Layer-by-Layer Assembly Approach Comparing Dip and Spin Coating
dc.date.accessioned2024-05-27T18:26:07Z
dc.date.available2024-05-27T18:26:07Z
dc.description.abstractThe design and engineering of antibacterial materials are key for preventing bacterial adherence and proliferation in biomedical and household instruments. Silver nanoparticles (AgNPs) and chitosan (CHI) are broad-spectrum antibacterial materials with different properties whose combined application is currently under optimization. This study proposes the formation of antibacterial films with AgNPs embedded in carboxymethylcellulose/chitosan multilayers by the layer-by-layer (LbL) method. The films were deposited onto nanoporous silicon (nPSi), an ideal platform for bioengineering applications due to its biocompatibility, biodegradability, and bioresorbability. We focused on two alternative multilayer deposition processes: cyclic dip coating (CDC) and cyclic spin coating (CSC). The physicochemical properties of the films were the subject of microscopic, microstructural, and surface-interface analyses. The antibacterial activity of each film was investigated against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) bacteria strains as model microorganisms. According to the findings, the CDC technique produced multilayer films with higher antibacterial activity for both bacteria compared to the CSC method. Bacteria adhesion inhibition was observed from only three cycles. The developed AgNPs-multilayer composite film offers advantageous antibacterial properties for biomedical applications.
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5688
dc.language.isoen
dc.publisherMDPI
dc.sourceINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
oaire.resourceTypeArticle
uct.indizacionSCI
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