Pharmacokinetics of levofloxacin after single intravenous and oral administration, and its interaction with sucralfate in mixed-breed dogs

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dc.contributor.authorUrzua, Natalia
dc.contributor.authorMessina, Maria Jimena
dc.contributor.authorCaverzan, Matias
dc.contributor.authorPrieto, Guillermo
dc.contributor.authorLüders Post, Carlos
dc.contributor.authorErrecalde, Carlos
dc.date2020
dc.date.accessioned2021-04-30T16:34:19Z
dc.date.available2021-04-30T16:34:19Z
dc.description.abstractThe study aims to establish the plasma pharmacokinetic parameters of levofloxacin in mixed-breed dogs, at a single dose of 5 mg/kg, intravenously, orally only and orally with sucralfate pre-treatment (1 g per animal), to evaluate its influence on antimicrobial absorption. Concentrations of levofloxacin in plasma were determined using high-performance liquid chromatography (HPLC) with fluorescence detection. After iv of levofloxacin, the mean (+/- SD) of AUC(0-24), Vz,t1/2 lambda z and MRT, was 19.05 +/- 6.4 mu g-h/ml, 2.43 +/- 0.5 L/kg, 7.93 +/- 1.41 hours and 8.7 +/- 1.5 hours, respectively. After oral administration, theC(max),t1/2 lambda z and bioavailability were 1.95 +/- 0.7 mu g/ml, 7.65 +/- 1.38 hours and 71.93 +/- 9.75%, respectively. In animals given an oral dose of levofloxacin with sucralfate pre-treatment, there was a significant decrease (p < 0.05) inC(max)(0.57 +/- 0.23 mu g/ml), AUC (5.73 +/- 2.26 mu g-h/ml) and bioavailability (31.92 +/- 14.19%). In the dogs studied, it is suggested that the dose 5 mg/kg of levofloxacin for both routes is inadequate to meet PK-PD targets for susceptible bacteria using breakpoints established by the Institute of Clinical and Laboratory Standards (CLSI).
dc.identifier.citationXENOBIOTICA,Vol.50,1490-1493,2020
dc.identifier.doi10.1080/00498254.2020.1793031
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3039
dc.language.isoen
dc.publisherTAYLOR & FRANCIS LTD
dc.sourceXENOBIOTICA
dc.subject.englishLevofloxacin
dc.subject.englishdogs
dc.subject.englishpharmacokinetics
dc.subject.englishsucralfate
dc.titlePharmacokinetics of levofloxacin after single intravenous and oral administration, and its interaction with sucralfate in mixed-breed dogs
dc.typeArticle
uct.catalogadorWOS
uct.indizacionSCI
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