Pharmacokinetics of levofloxacin after single intravenous and oral administration, and its interaction with sucralfate in mixed-breed dogs
Pharmacokinetics of levofloxacin after single intravenous and oral administration, and its interaction with sucralfate in mixed-breed dogs
Authors
Urzua, Natalia
Messina, Maria Jimena
Caverzan, Matias
Prieto, Guillermo
Lüders Post, Carlos
Errecalde, Carlos
Messina, Maria Jimena
Caverzan, Matias
Prieto, Guillermo
Lüders Post, Carlos
Errecalde, Carlos
Authors
Date
Datos de publicación:
10.1080/00498254.2020.1793031
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Abstract
The study aims to establish the plasma pharmacokinetic parameters of levofloxacin in mixed-breed dogs, at a single dose of 5 mg/kg, intravenously, orally only and orally with sucralfate pre-treatment (1 g per animal), to evaluate its influence on antimicrobial absorption. Concentrations of levofloxacin in plasma were determined using high-performance liquid chromatography (HPLC) with fluorescence detection. After iv of levofloxacin, the mean (+/- SD) of AUC(0-24), Vz,t1/2 lambda z and MRT, was 19.05 +/- 6.4 mu g-h/ml, 2.43 +/- 0.5 L/kg, 7.93 +/- 1.41 hours and 8.7 +/- 1.5 hours, respectively. After oral administration, theC(max),t1/2 lambda z and bioavailability were 1.95 +/- 0.7 mu g/ml, 7.65 +/- 1.38 hours and 71.93 +/- 9.75%, respectively. In animals given an oral dose of levofloxacin with sucralfate pre-treatment, there was a significant decrease (p < 0.05) inC(max)(0.57 +/- 0.23 mu g/ml), AUC (5.73 +/- 2.26 mu g-h/ml) and bioavailability (31.92 +/- 14.19%). In the dogs studied, it is suggested that the dose 5 mg/kg of levofloxacin for both routes is inadequate to meet PK-PD targets for susceptible bacteria using breakpoints established by the Institute of Clinical and Laboratory Standards (CLSI).