MicroRNAs as Potential Biomarkers of Environmental Exposure to Polycyclic Aromatic Hydrocarbons and Their Link with Inflammation and Lung Cancer
MicroRNAs as Potential Biomarkers of Environmental Exposure to Polycyclic Aromatic Hydrocarbons and Their Link with Inflammation and Lung Cancer
Authors
Letelier, Pablo
Saldias, Rolando
Loren, Pia
Riquelme, Ismael
Guzman, Neftali
Saldias, Rolando
Loren, Pia
Riquelme, Ismael
Guzman, Neftali
Profesor GuĆa
Authors
Date
Datos de publicaciĆ³n:
10.3390/ijms242316984
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,Vol.24,2023
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,Vol.24,2023
Tipo de recurso
Review
Keywords
Materia geogrƔfica
Collections
Abstract
Exposure to atmospheric air pollution containing volatile organic compounds such as polycyclic aromatic hydrocarbons (PAHs) has been shown to be a risk factor in the induction of lung inflammation and the initiation and progression of lung cancer. MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules of similar to 20-22 nucleotides that regulate different physiological processes, and their altered expression is implicated in various pathophysiological conditions. Recent studies have shown that the regulation of gene expression of miRNAs can be affected in diseases associated with outdoor air pollution, meaning they could also be useful as biomarkers of exposure to environmental pollution. In this article, we review the published evidence on miRNAs in relation to exposure to PAH pollution and discuss the possible mechanisms that may link these compounds with the expression of miRNAs.