Antibacterial Films of Silver Nanoparticles Embedded into Carboxymethylcellulose/Chitosan Multilayers on Nanoporous Silicon: A Layer-by-Layer Assembly Approach Comparing Dip and Spin Coating
Date
Authors
HERNANDEZ MONTELONGO, JESUS JACOBO
Naveas, Nelson
Pulido, Ruth
Torres-Costa, Vicente
Agulló-Rueda, Fernando
Santibáñez, Mauricio
Malano, Francisco
Recio-Sánchez, Gonzalo
Garrido-Miranda, Karla A.
Manso, Miguel Jose
Hernández-Montelongo, Jacobo
Naveas, Nelson
Pulido, Ruth
Torres-Costa, Vicente
Agulló-Rueda, Fernando
Santibáñez, Mauricio
Malano, Francisco
Recio-Sánchez, Gonzalo
Garrido-Miranda, Karla A.
Manso, Miguel Jose
Hernández-Montelongo, Jacobo
Authors
Date
Datos de publicación:
10.3390/ijms241310595
Keywords
Antibacterial Films - Carboxymethylcellulose - Chitosan - Composite Material - Layer-by-layer - Nanoporous Silicon - Silver Nanoparticles - Carboxymethylcellulose - Chitosan - Silicon - Silver - Anti-bacterial Agents - Carboxymethylcellulose Sodium - Chitosan - Silicon - Silver - Antiinfective Agent - Carboxymethylcellulose - Chitosan - Nanoporous Material - Silicon - Silver Nanoparticle - Layer By Layer Nanoparticle - Metal Nanoparticle - Silver - Antibacterial Activity - Article - Bacterial Strain - Bacterium Adherence - Biocompatibility - Biodegradability - Bioengineering - Controlled Study - Dip Coating - Escherichia Coli - Gram Positive Bacterium - Nonhuman - Spin Coating - Staphylococcus Aureus - Surface Analysis - Chemistry - Anti-bacterial Agents - Bacterial Adhesion - Carboxymethylcellulose Sodium - Chitosan - Layer-by-layer Nanoparticles - Metal Nanoparticles - Nanopores - Silicon - Silver
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Abstract
The design and engineering of antibacterial materials are key for preventing bacterial adherence and proliferation in biomedical and household instruments. Silver nanoparticles (AgNPs) and chitosan (CHI) are broad-spectrum antibacterial materials with different properties whose combined application is currently under optimization. This study proposes the formation of antibacterial films with AgNPs embedded in carboxymethylcellulose/chitosan multilayers by the layer-by-layer (LbL) method. The films were deposited onto nanoporous silicon (nPSi), an ideal platform for bioengineering applications due to its biocompatibility, biodegradability, and bioresorbability. We focused on two alternative multilayer deposition processes: cyclic dip coating (CDC) and cyclic spin coating (CSC). The physicochemical properties of the films were the subject of microscopic, microstructural, and surface interface analyses. The antibacterial activity of each film was investigated against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) bacteria strains as model microorganisms. According to the findings, the CDC technique produced multilayer films with higher antibacterial activity for both bacteria compared to the CSC method. Bacteria adhesion inhibition was observed from only three cycles. The developed AgNPs multilayer composite film offers advantageous antibacterial properties for biomedical applications. © 2023 Elsevier B.V., All rights reserved.
Description
Keywords
Antibacterial Films , Carboxymethylcellulose , Chitosan , Composite Material , Layer-by-layer , Nanoporous Silicon , Silver Nanoparticles , Carboxymethylcellulose , Chitosan , Silicon , Silver , Anti-bacterial Agents , Carboxymethylcellulose Sodium , Chitosan , Silicon , Silver , Antiinfective Agent , Carboxymethylcellulose , Chitosan , Nanoporous Material , Silicon , Silver Nanoparticle , Layer By Layer Nanoparticle , Metal Nanoparticle , Silver , Antibacterial Activity , Article , Bacterial Strain , Bacterium Adherence , Biocompatibility , Biodegradability , Bioengineering , Controlled Study , Dip Coating , Escherichia Coli , Gram Positive Bacterium , Nonhuman , Spin Coating , Staphylococcus Aureus , Surface Analysis , Chemistry , Anti-bacterial Agents , Bacterial Adhesion , Carboxymethylcellulose Sodium , Chitosan , Layer-by-layer Nanoparticles , Metal Nanoparticles , Nanopores , Silicon , Silver
Citation
10.3390/ijms241310595