Aspergillus fumigatus-sensitive IgE is associated with bronchial hypersensitivity in a murine model of neutrophilic airway inflammation

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datacite.alternateIdentifier.citationJournal of Medical Mycology, 28 (1), 136-128, 2018
datacite.alternateIdentifier.doi10.1016/j.mycmed.2017.11.005
datacite.alternateIdentifier.issn1773-0449
datacite.creatorMorán, Gabriel
datacite.creatorUberti, Benjamin
datacite.creatorOrtloff, Alexander R.
datacite.creatorFolch, Hugo
datacite.date2018
datacite.rightsRegistro bibliográfico
datacite.subjectAspergillus Fumigatus
datacite.subjectIge
datacite.subjectNeutrophilic Asthma
datacite.subjectImmunoglobulin E
datacite.subjectFungal Proteins
datacite.subjectImmunoglobulin E
datacite.subjectFungal Extract
datacite.subjectFungal Protein
datacite.subjectImmunoglobulin E
datacite.subjectImmunoglobulin E Antibody
datacite.subjectAnimal Cell
datacite.subjectAnimal Experiment
datacite.subjectAnimal Model
datacite.subjectAnimal Tissue
datacite.subjectArticle
datacite.subjectAspergillosis
datacite.subjectAspergillus Fumigatus
datacite.subjectAsthma
datacite.subjectBronchial Hypersensitivity
datacite.subjectBronchoalveolar Lavage Fluid
datacite.subjectCell Activation
datacite.subjectControlled Study
datacite.subjectCytology
datacite.subjectDisease Association
datacite.subjectDisease Severity
datacite.subjectEnzyme Linked Immunosorbent Assay
datacite.subjectHistology
datacite.subjectLung Parenchyma
datacite.subjectMast Cell Degranulation
datacite.subjectMouse
datacite.subjectNeutrophil
datacite.subjectNeutrophilic Airway Inflammation
datacite.subjectNonhuman
datacite.subjectProtein Function
datacite.subjectRat
datacite.subjectRespiratory Tract Allergy
datacite.subjectRespiratory Tract Inflammation
datacite.subjectAnimal
datacite.subjectBagg Albino Mouse
datacite.subjectBioassay
datacite.subjectBronchus Hyperreactivity
datacite.subjectChemistry
datacite.subjectDisease Model
datacite.subjectFemale
datacite.subjectFungus Spore
datacite.subjectHypersensitivity
datacite.subjectImmunology
datacite.subjectInflammation
datacite.subjectLung
datacite.subjectMast Cell
datacite.subjectMicrobiology
datacite.subjectPathology
datacite.subjectPathophysiology
datacite.subjectAnimals
datacite.subjectAsthma
datacite.subjectBiological Assay
datacite.subjectBronchial Hyperreactivity
datacite.subjectBronchoalveolar Lavage Fluid
datacite.subjectDisease Models, Animal
datacite.subjectFemale
datacite.subjectFungal Proteins
datacite.subjectHypersensitivity
datacite.subjectImmunoglobulin E
datacite.subjectInflammation
datacite.subjectLung
datacite.subjectMast Cells
datacite.subjectMice
datacite.subjectMice, Inbred Balb C
datacite.subjectNeutrophils
datacite.subjectSpores, Fungal
datacite.titleAspergillus fumigatus-sensitive IgE is associated with bronchial hypersensitivity in a murine model of neutrophilic airway inflammation
dc.contributor.authorORTLOFF TRAUTMANN, ALEXANDER
dc.date.accessioned2025-10-06T14:21:58Z
dc.date.available2025-10-06T14:21:58Z
dc.description.abstractNeutrophils are the predominant inflammatory cells that infiltrate airways during acute exacerbation of asthma. The importance of A. fumigatus sensitization, and IgE response in the airways in patients with acute asthma is unclear. Rockefeller (RK) mice were sensitized with A. fumigatus extract protein. The animals were subsequently challenged with different degrees of A. fumigatus contamination in the cage bedding. All groups of mice were euthanized to obtain bronchoalveolar lavage fluid (BALF) for cytological and Elisa assays, and lung tissue for histological analysis. Moreover, several bioassays were conducted to determine whether BALF IgE antibodies can activate mast cells. In this study, we demonstrated that exposure of sensitized mice to a known concentration of A. fumigatus conidia produces bronchial hyperreactivity with marked neutrophilic bronchial infiltration and increased BALF IgE, capable of triggering mast cell degranulation. This study suggests that IgE may play a role in bronchial hyperreactivity associated to A. fumigatus exposure in mice. Mice sensitized and challenged with this fungus showed characteristics of severe asthma, with an increase of BALF neutrophils, histological changes consistent with severe asthma and an increase of IgE capable of triggering type I hypersensitivity. © 2019 Elsevier B.V., All rights reserved.
dc.description.ia_keywordfumigatus, mice, asthma, were, balf, bronchial, sensitized
dc.identifier.issn1156-5233
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/6883
dc.language.isoen
dc.publisherElsevier BV
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourceJournal of Medical Mycology
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Biológicas
dc.subject.ia_oecd3nBiología General
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2018
oaire.citationEndPage136
oaire.citationIssue1
oaire.citationStartPage128
oaire.citationTitleJournal of Medical Mycology
oaire.citationVolume28
oaire.fundingReferenceCONICYT ANID FONDECYT 1160352 (Regular)
oaire.licenseConditionCopyright © Elsevier Masson SAS, 2017
oaire.resourceTypeArtículo
oaire.resourceType.enArticle
relation.isAuthorOfPublication798755f1-1bb9-449a-b2e2-d4bbe38ca016
relation.isAuthorOfPublication.latestForDiscovery798755f1-1bb9-449a-b2e2-d4bbe38ca016
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Veterinarias y Salud Pública
uct.facultadFacultad de Recursos Naturales
uct.indizacionScopus
uct.indizacionPubMed/MEDLINE
uct.indizacionEMBASE
uct.indizacionEmerging Sources Citation Index - ESCI
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