Adjuvant Properties of Caffeic Acid in Cancer Treatment

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datacite.alternateIdentifier.citationInternational Journal of Molecular Sciences, 25 (14), 2024
datacite.alternateIdentifier.doi10.3390/ijms25147631
datacite.alternateIdentifier.issn1422-0067
datacite.creatorCortez, Nicole
datacite.creatorVillegas, Cecilia
datacite.creatorBurgos, Viviana
datacite.creatorCabrera-Pardo, Jaime R.
datacite.creatorOrtíz, Leandro
datacite.creatorGonzález-Chavarría, Iván
datacite.creatorNchiozem-Ngnitedem, Vaderament A.
datacite.creatorPaz, Cristian
datacite.date2024
datacite.rightsAcceso abierto
datacite.subjectAdjuvant Cancer Treatment
datacite.subjectCaffeic Acid
datacite.subjectMetabolism
datacite.subjectVegetal Sources
datacite.subjectAmino Acid
datacite.subjectCaffeic Acid
datacite.subjectMitogen Activated Protein Kinase 1
datacite.subjectMitogen Activated Protein Kinase 3
datacite.subjectPhenylalanine
datacite.subjectPolyphenol
datacite.subjectAntineoplastic Agents
datacite.subjectAntioxidants
datacite.subjectCaffeic Acid
datacite.subjectCaffeic Acids
datacite.subjectAmino Acid
datacite.subjectAntioxidant
datacite.subjectCaffeic Acid
datacite.subjectMitogen Activated Protein Kinase 1
datacite.subjectMitogen Activated Protein Kinase 3
datacite.subjectPhenylalanine
datacite.subjectPolyphenol
datacite.subjectStat3 Protein
datacite.subjectAntineoplastic Agent
datacite.subjectCaffeic Acid Derivative
datacite.subjectAntineoplastic Activity
datacite.subjectCancer Inhibition
datacite.subjectCancer Therapy
datacite.subjectDrug Resistance
datacite.subjectDrug Therapy
datacite.subjectHeadache
datacite.subjectHuman
datacite.subjectMalignant Neoplasm
datacite.subjectNonhuman
datacite.subjectPrevention
datacite.subjectReview
datacite.subjectTherapy
datacite.subjectAnimal
datacite.subjectMetabolism
datacite.subjectNeoplasm
datacite.subjectAnimals
datacite.subjectAntineoplastic Agents
datacite.subjectAntioxidants
datacite.subjectCaffeic Acids
datacite.subjectHumans
datacite.subjectNeoplasms
datacite.titleAdjuvant Properties of Caffeic Acid in Cancer Treatment
dc.description.abstractCaffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product of caffetannic acid. CA is biosynthesized from the amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including its antioxidant, anti-inflammatory, and anticancer properties. These effects are attributed to its ability to modulate several pathways, such as inhibiting NFkB, STAT3, and ERK1/2, thereby reducing inflammatory responses, and activating the Nrf2/ARE pathway to enhance antioxidant cell defenses. The consumption of CA has been linked to a reduced risk of certain cancers, mitigation of chemotherapy and radiotherapy-induced toxicity, and reversal of resistance to first-line chemotherapeutic agents. This suggests that CA could serve as a useful adjunct in cancer treatment. Studies have shown CA to be generally safe, with few adverse effects (such as back pain and headaches) reported. This review collates the latest information from Google Scholar, PubMed, the Phenol-Explorer database, and ClinicalTrials.gov, incorporating a total of 154 articles, to underscore the potential of CA in cancer prevention and overcoming chemoresistance. © 2024 Elsevier B.V., All rights reserved.
dc.description.ia_keywordacid, cancer, caffeic, first, antioxidant, inflammatory, properties
dc.formatPDF
dc.identifier.issn1661-6596
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5942
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relationinstname: ANID
dc.relationreponame: Repositorio Digital RI2.0
dc.rights.driverinfo:eu-repo/semantics/openAccess
dc.sourceInternational Journal of Molecular Sciences
dc.subject.ia_odsODS 3: Salud y bienestar
dc.subject.ia_oecd1nCiencias Naturales
dc.subject.ia_oecd2nCiencias Biológicas
dc.subject.ia_oecd3nBiología General
dc.type.driverinfo:eu-repo/semantics/article
dc.type.driverhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaireinfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
oaire.citationEdition2024
oaire.citationIssue14
oaire.citationTitleInternational Journal of Molecular Sciences
oaire.citationVolume25
oaire.fundingReferenceANID FONDECYT 1220831
oaire.licenseConditionObra bajo licencia Creative Commons Atribución 4.0 Internacional
oaire.licenseCondition.urihttps://creativecommons.org/licenses/by/4.0/
oaire.resourceTypeArtículo de revisión
oaire.resourceType.enReview
uct.catalogadorjvu
uct.comunidadRecursos Naturalesen_US
uct.departamentoDepartamento de Ciencias Biológicas y Químicas
uct.facultadFacultad de Recursos Naturales
uct.indizacionScience Citation Index Expanded - SCIE
uct.indizacionScopus
uct.indizacionPubMed Central (PMC)
uct.indizacionChemical Abstracts Service (CAS)
uct.indizacionMEDLINE
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