Adjuvant Properties of Caffeic Acid in Cancer Treatment
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Date
Authors
Cortez, Nicole
Villegas, Cecilia
Burgos, Viviana
Cabrera-Pardo, Jaime R.
Ortíz, Leandro
González-Chavarría, Iván
Nchiozem-Ngnitedem, Vaderament A.
Paz, Cristian
Villegas, Cecilia
Burgos, Viviana
Cabrera-Pardo, Jaime R.
Ortíz, Leandro
González-Chavarría, Iván
Nchiozem-Ngnitedem, Vaderament A.
Paz, Cristian
Authors
Date
Datos de publicación:
10.3390/ijms25147631
Keywords
Adjuvant Cancer Treatment - Caffeic Acid - Metabolism - Vegetal Sources - Amino Acid - Caffeic Acid - Mitogen Activated Protein Kinase 1 - Mitogen Activated Protein Kinase 3 - Phenylalanine - Polyphenol - Antineoplastic Agents - Antioxidants - Caffeic Acid - Caffeic Acids - Amino Acid - Antioxidant - Caffeic Acid - Mitogen Activated Protein Kinase 1 - Mitogen Activated Protein Kinase 3 - Phenylalanine - Polyphenol - Stat3 Protein - Antineoplastic Agent - Caffeic Acid Derivative - Antineoplastic Activity - Cancer Inhibition - Cancer Therapy - Drug Resistance - Drug Therapy - Headache - Human - Malignant Neoplasm - Nonhuman - Prevention - Review - Therapy - Animal - Metabolism - Neoplasm - Animals - Antineoplastic Agents - Antioxidants - Caffeic Acids - Humans - Neoplasms
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Abstract
Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product of caffetannic acid. CA is biosynthesized from the amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including its antioxidant, anti-inflammatory, and anticancer properties. These effects are attributed to its ability to modulate several pathways, such as inhibiting NFkB, STAT3, and ERK1/2, thereby reducing inflammatory responses, and activating the Nrf2/ARE pathway to enhance antioxidant cell defenses. The consumption of CA has been linked to a reduced risk of certain cancers, mitigation of chemotherapy and radiotherapy-induced toxicity, and reversal of resistance to first-line chemotherapeutic agents. This suggests that CA could serve as a useful adjunct in cancer treatment. Studies have shown CA to be generally safe, with few adverse effects (such as back pain and headaches) reported. This review collates the latest information from Google Scholar, PubMed, the Phenol-Explorer database, and ClinicalTrials.gov, incorporating a total of 154 articles, to underscore the potential of CA in cancer prevention and overcoming chemoresistance. © 2024 Elsevier B.V., All rights reserved.
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Keywords
Adjuvant Cancer Treatment , Caffeic Acid , Metabolism , Vegetal Sources , Amino Acid , Caffeic Acid , Mitogen Activated Protein Kinase 1 , Mitogen Activated Protein Kinase 3 , Phenylalanine , Polyphenol , Antineoplastic Agents , Antioxidants , Caffeic Acid , Caffeic Acids , Amino Acid , Antioxidant , Caffeic Acid , Mitogen Activated Protein Kinase 1 , Mitogen Activated Protein Kinase 3 , Phenylalanine , Polyphenol , Stat3 Protein , Antineoplastic Agent , Caffeic Acid Derivative , Antineoplastic Activity , Cancer Inhibition , Cancer Therapy , Drug Resistance , Drug Therapy , Headache , Human , Malignant Neoplasm , Nonhuman , Prevention , Review , Therapy , Animal , Metabolism , Neoplasm , Animals , Antineoplastic Agents , Antioxidants , Caffeic Acids , Humans , Neoplasms
Citation
10.3390/ijms25147631