Recurrent respiratory papillomatosis in a pediatric patient: case report
- Benavente Muñoz, Felipe - Contreras, Marcelo - Perferi, Giancarlo - Azzari, Chiara - Munoz, Mariela - Inostroza, Jaime
- Datos de publicación:
- REVISTA CHILENA DE PEDIATRIA-CHILE,Vol.88,393-397,2017
- HLA-alleles - recurrent respiratory - papillomatosis
- Migración Web of Science 
- Introduction: Genetic variability related to the host immune system has been proposed as one of the most influential factors in the development of diseases caused by HPV. Clinical case: We report the case of a 5-year-old child in whom chronic laryngeal papillomatosis, probably acquired vertically during labor, was detected. The diagnosis of laryngeal papillomatosis was confirmed with a biopsy after a first surgery to remove the papillomas. The Derkay classification system was used to assess the severity of papillomatosis. Biopsy genotyping was performed by demonstrating HPV-6. Later, HLADQA1*0505, -DQB1*0301, -DRB1*1101 alleles were homozygous for HLA allele typing. Conclusions: Further studies are needed to identify the most prevalent HLA alleles in the Latino population and their potential association with genetic susceptibility in Recurrent Respiratory Papillomatosis.