Recurrent respiratory papillomatosis in a pediatric patient: case report
Recurrent respiratory papillomatosis in a pediatric patient: case report
Authors
Benavente Muñoz, Felipe
Contreras, Marcelo
Perferi, Giancarlo
Azzari, Chiara
Munoz, Mariela
Inostroza, Jaime
Contreras, Marcelo
Perferi, Giancarlo
Azzari, Chiara
Munoz, Mariela
Inostroza, Jaime
Authors
Date
Datos de publicación:
REVISTA CHILENA DE PEDIATRIA-CHILE,Vol.88,393-397,2017
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Abstract
Introduction: Genetic variability related to the host immune system has been proposed as one of the most influential factors in the development of diseases caused by HPV. Clinical case: We report the case of a 5-year-old child in whom chronic laryngeal papillomatosis, probably acquired vertically during labor, was detected. The diagnosis of laryngeal papillomatosis was confirmed with a biopsy after a first surgery to remove the papillomas. The Derkay classification system was used to assess the severity of papillomatosis. Biopsy genotyping was performed by demonstrating HPV-6. Later, HLADQA1*0505, -DQB1*0301, -DRB1*1101 alleles were homozygous for HLA allele typing. Conclusions: Further studies are needed to identify the most prevalent HLA alleles in the Latino population and their potential association with genetic susceptibility in Recurrent Respiratory Papillomatosis.