Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer

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Autor:
Buchegger, Kurt - Lopez, Jaime - Ili, Carmen - Riquelme, Ismael - Letelier, Pablo - Guzman, Pablo - Bellolio, Enrique - Corvalan, Alejandro H. - Brebi, Priscilla - Carlos Roa, Juan
URI:
http://repositoriodigital.uct.cl/handle/10925/3600
Datos de publicación:
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,Vol.9,3025-3032,2016
Temas:
Immunohistochemistry - RPRM - breast cancer - Ki67
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Resumen:
Reprimo (RPRM) is a potential p53-dependent tumor suppressor gene, which plays an important role in cell cycle arrest at G(2)/M checkpoint. The aim of this study was to characterize RPRM protein expression in breast cancer tissues and its relation with clinic-pathologic features and proliferation marker protein Ki67. RPRM protein expression was examined by immunohistochemistry in tissue microarray containing 275-breast cancer and 16 normal breast tissues. These cases were classified as negative or positive expression for RPRM expression level with clinic-pathologic variables. The Kaplan-Meier curve was used to estimate survival over time. Positive expression of RPRM was observed in 68.4% (188/275) of tumors and 100% of breast normal tissues (16/16). RPRM expression has a significant relationship with age (P = 0.000). Moreover, positive RPRM expression was significant associated with low expression of proliferation marker protein Ki67; however, survival analysis did not show significant differences. These results suggest that RPRM is not a good prognosis marker but likely had an important role modulating negatively cell proliferation in breast cancer tissues.

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