Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer

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dc.contributor.authorBuchegger, Kurt
dc.contributor.authorLopez, Jaime
dc.contributor.authorIli, Carmen
dc.contributor.authorRiquelme, Ismael
dc.contributor.authorLetelier, Pablo
dc.contributor.authorGuzman, Pablo
dc.contributor.authorBellolio, Enrique
dc.contributor.authorCorvalan, Alejandro H.
dc.contributor.authorBrebi, Priscilla
dc.contributor.authorCarlos Roa, Juan
dc.date2016
dc.date.accessioned2021-04-30T16:47:52Z
dc.date.available2021-04-30T16:47:52Z
dc.description.abstractReprimo (RPRM) is a potential p53-dependent tumor suppressor gene, which plays an important role in cell cycle arrest at G(2)/M checkpoint. The aim of this study was to characterize RPRM protein expression in breast cancer tissues and its relation with clinic-pathologic features and proliferation marker protein Ki67. RPRM protein expression was examined by immunohistochemistry in tissue microarray containing 275-breast cancer and 16 normal breast tissues. These cases were classified as negative or positive expression for RPRM expression level with clinic-pathologic variables. The Kaplan-Meier curve was used to estimate survival over time. Positive expression of RPRM was observed in 68.4% (188/275) of tumors and 100% of breast normal tissues (16/16). RPRM expression has a significant relationship with age (P = 0.000). Moreover, positive RPRM expression was significant associated with low expression of proliferation marker protein Ki67; however, survival analysis did not show significant differences. These results suggest that RPRM is not a good prognosis marker but likely had an important role modulating negatively cell proliferation in breast cancer tissues.
dc.identifier.citationINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,Vol.9,3025-3032,2016
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3600
dc.language.isoen
dc.publisherE-CENTURY PUBLISHING CORP
dc.sourceINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
dc.subject.englishImmunohistochemistry
dc.subject.englishRPRM
dc.subject.englishbreast cancer
dc.subject.englishKi67
dc.titleImmunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer
dc.typeArticle
uct.catalogadorWOS
uct.indizacionSCI
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