A bioinformatics analysis of the CatSper channel in the class Actinopterygii

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datacite.alternateIdentifier.citationCOMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY,Vol.267,2022
datacite.alternateIdentifier.doi10.1016/j.cbpa.2022.111181
datacite.creatorBeltran, Jorge F.
datacite.creatorParraguez Contreras, Fernanda
datacite.creatorNorambuena, Juan Alejandro
datacite.creatorHerrera Belen, Lisandra
datacite.creatorRisopatron, Jennie
datacite.creatorValdebenito, Ivan
datacite.creatorFigueroa, Elias
datacite.creatorFarias, Jorge G.
datacite.date2022
datacite.subject.englishFish
datacite.subject.englishCatSper
datacite.subject.englishBioinformatics
datacite.subject.englishSperm
datacite.subject.englishActinopterygii
datacite.titleA bioinformatics analysis of the CatSper channel in the class Actinopterygii
dc.date.accessioned2022-06-06T21:30:40Z
dc.date.available2022-06-06T21:30:40Z
dc.description.abstractThe regulation of sperm motility is controlled by several variables, including mainly ion concentrations. In fish, Ca2+ concentrations play an important role in the regulation of sperm motility, and several reports highlight the importance of certain Ca2+ channels in the regulation of this cell function. CatSper is a calcium channel scarcely studied in fish. In the species Salmo salar, it has been shown that it is key in the regulation of sperm motility. Taking into account the relevance of this channel in sperm activation in fish, in this study we evaluated the presence and probable functionality of this channel in the class Actinopterygii. For this purpose, a rational bioinformatic analysis was carried out, which had been previously validated using in vitro techniques by our group. The bioinformatic analysis of the present work revealed that the functionality of CatSper of the species of the class Actinopterygii could be exclusive to freshwater and anadromous fish species. The results of this study showed that only some anadromous and freshwater fish species contain 11 subunits of the CatSper channel, which are enough to trigger sperm motility. Consequently, this study provides new data for a better under-standing of the sperm activation mechanism in fish.
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/4567
dc.language.isoen
dc.publisherELSEVIER SCIENCE INC
dc.sourceCOMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
oaire.resourceTypeArticle
uct.indizacionSCI
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