Carbonate-beta-Cyclodextrin-Based Nanosponge as a Nanoencapsulation System for Piperine: Physicochemical Characterization

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dc.contributor.authorGarrido, B.
dc.contributor.authorGonzalez, S.
dc.contributor.authorHermosilla, J.
dc.contributor.authorMillao, S.
dc.contributor.authorQuilaqueo, M.
dc.contributor.authorGuineo, J.
dc.contributor.authorAcevedo, F.
dc.contributor.authorPesenti Pérez, Héctor
dc.contributor.authorRolleri, A.
dc.contributor.authorShene, C.
dc.contributor.authorRubilar, M.
dc.date2019
dc.date.accessioned2021-04-30T16:47:47Z
dc.date.available2021-04-30T16:47:47Z
dc.description.abstractPiperine (PIP) is a nitrogenous substance whose application in food is still limited due to its low solubility in water, low bioavailability, and high pungency. Nanosponges (NS) can selectively capture, transport, and release a wide variety of substances and mask unpleasant flavors. The objective of this study was to evaluate carbonate-beta-cyclodextrin-based NS formation as a nanoencapsulation system for PIP. The NS were formed with a cyclic oligosaccharide (beta-cyclodextrin) to a cross-linker (diphenyl carbonate) at molar ratios of 1:2, 1:6, and 1:10 by the solvent method at 90, 120, and 150 degrees C for 5 h. Only molar ratios of 1:6 and 1:10 formed NS. The NS 1:6 at 90 degrees C with loading efficiency of 42.6% +/- 1.1 was the best alternative for loading PIP in the NS matrix because it had the lowest absorbance of cyclic carbonates and required the lowest amount of cross-linker in its formation. The ability of the cyclodextrin-based NS to encapsulate PIP was confirmed by FTIR studies and hyperspectral FTIR images, TGA, and DSC, showing that PIP is dispersed, not forming large clusters, or concentrating in a single zone. NS are an effective PIP encapsulation system and protect the bioactive properties of the PIP.
dc.identifier.citationJOURNAL OF SOIL SCIENCE AND PLANT NUTRITION,Vol.19,620-630,2019
dc.identifier.doi10.1007/s42729-019-00062-7
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3511
dc.language.isoen
dc.publisherSPRINGER INTERNATIONAL PUBLISHING AG
dc.sourceJOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
dc.subject.englishPiperine
dc.subject.englishbeta-Cyclodextrin
dc.subject.englishNanosponges
dc.subject.englishNanoencapsulation
dc.subject.englishSolvent method
dc.subject.englishInclusion complex
dc.titleCarbonate-beta-Cyclodextrin-Based Nanosponge as a Nanoencapsulation System for Piperine: Physicochemical Characterization
dc.typeArticle
uct.catalogadorWOS
uct.indizacionSCI
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