Synthesis and properties of silk fibroin/Konjac glucomannan blend beads

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dc.contributor.authorFranca, Carla Giometti
dc.contributor.authorNascimento, Vicente Franco
dc.contributor.authorHernández Montelongo, Jacobo
dc.contributor.authorMachado, Daisy
dc.contributor.authorLancellotti, Marcelo
dc.contributor.authorBeppu, Marisa
dc.date2018
dc.date.accessioned2020-07-09T21:57:57Z
dc.date.available2020-07-09T21:57:57Z
dc.description.abstractSilk fibroin (SF) and konjac glucomannan (KGM) are promising materials in the biomedical field due to their low toxicity, biocompatibility, biodegradability and low immune response. Beads of these natural polymers are interesting scaffolds for biomedical applications, but their fabrication is a challenge due to their low stability and the necessary adaptation of their chemical and mechanical properties to be successfully applied. In that sense, this study aimed to synthesize a blend of silk fibroin and konjac glucomannan (SF/KGM) in the form of porous beads obtained through dripping into liquid nitrogen, with a post-treatment using ethanol. Intermolecular hydrogen bonds promoted the integration of SF and KGM. Treated beads showed higher porous size, crystallinity, and stability than untreated beads. Characterization analyses by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric (TGA), and X-ray diffraction (XDR) evidenced that ethanol treatment allows a conformational transition from silk I to silk II in SF and an increase in the KGM deacetylation. Those chemical changes significantly enhanced the mechanical resistance of SF/KGM beads in comparison to pure SF and KGM beads. Moreover, samples showed cytocompatibility with HaCaT and BALB/c 3T3 cellsen_US
dc.formatPDFen_US
dc.identifier.citationPolymers, Vol.10, N°8, 18en_US
dc.identifier.doi10.3390/polym10080923en_US
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/2265
dc.language.isoenen_US
dc.rightsObra bajo licencia Creative Commons 3.0en_US
dc.sourcePolymers, Vol.10, N°8, 18en_US
dc.subjectKonjac glucomannanen_US
dc.subjectIngeniería de tejidosen_US
dc.subjectFibroínaen_US
dc.subjectFibra de sedaen_US
dc.subjectDragalinaen_US
dc.titleSynthesis and properties of silk fibroin/Konjac glucomannan blend beadsen_US
dc.typeArtículo de Revistaen_US
uct.catalogadormlmen_US
uct.comunidadRecursos Naturalesen_US
uct.disciplinaCiencias y Tecnología de los Alimentosen_US
uct.indizacionSCOPUSen_US
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