Differential Pulse Voltammetry Determination of Anti-Hypertensive Drug Hydrochlorothiazide in Pharmaceuticals Using Glassy-Carbon Electrode Modified by Electropolymerization with L- and D-Glutamic Acids
datacite.alternateIdentifier.citation | International Journal of Electrochemical Science, Vol.13, N°2, 1905-1920, 2018 | |
datacite.alternateIdentifier.doi | 10.20964/2018.02.10 | es_ES |
datacite.creator | González Vargas, Camilo | |
datacite.creator | García, Camilo | |
datacite.creator | Celis, Freddy | |
datacite.creator | Salazar, Ricardo | |
datacite.date | 2018 | |
datacite.date.issued | 2019-10-30 | |
datacite.subject | Differential pulse voltammetry | es_ES |
datacite.subject | Electropolymerization | es_ES |
datacite.subject | Glassy carbon electrode | es_ES |
datacite.subject | Glutamic Acid | es_ES |
datacite.subject | Hydrochlorotiazide | es_ES |
datacite.title | Differential Pulse Voltammetry Determination of Anti-Hypertensive Drug Hydrochlorothiazide in Pharmaceuticals Using Glassy-Carbon Electrode Modified by Electropolymerization with L- and D-Glutamic Acids | es_ES |
dc.date.accessioned | 2019-10-30T14:18:31Z | |
dc.date.available | 2019-10-30T14:18:31Z | |
dc.description.abstract | A simple and sensitive electrochemical sensor based on glassy carbon electrode modified by electropolymerization with both poly-glutamic acid enantiomers L- and D (GC-PGA) was developed to detect the anti-hypertensive drug hydrochlorotiazide (6-chloro-3,4-di-hydro-2H-1, 2,4-benzothiadiazine-7-sulfonamide-1,1 dioxide, HCTZ) in pharmaceuticals samples. Raman spectroscopy and electrochemical impedance spectroscopy were carried out to characterize L-PGA and D-PGA film. These procedures confirm the production of a polymer through an amide bond and the formation of a film resistant to charge transference in both cases. Also, an increase in the oxidation peak current for HCTZ in Buffer Britton Robinson solution 0,1 M pH 2 was obtained using the modified electrodes. With GC/D-PGA and GC/L-PGA, the peak current increased 2 times compared to unmodified GC, when using differential pulse voltammetry. A novel electroanalytical method for the determination of HCTZ was developed with both modified electrodes, showing a less limit of determination: 0.03186 and 0.01829 mM to GC/L-PGA and GC/D-PGA, respectively, and a less limit of quantification with respect to the GC electrode. The methodology developed was applied in the determination of HCTZ from pharmaceutical forms | es_ES |
dc.format | es_ES | |
dc.identifier.uri | http://repositoriodigital.uct.cl/handle/10925/2047 | |
dc.language.iso | es | es_ES |
dc.source | International Journal of Electrochemical Science | es_ES |
oaire.resourceType | Artículo de Revista | es_ES |
uct.catalogador | pop | es_ES |
uct.comunidad | Ingeniería | es_ES |
uct.disciplina | Ingeniería Química | es_ES |
uct.indizacion | ISI - Science Citation Index | es_ES |
uct.indizacion | SCOPUS | es_ES |
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