Differential Pulse Voltammetry Determination of Anti-Hypertensive Drug Hydrochlorothiazide in Pharmaceuticals Using Glassy-Carbon Electrode Modified by Electropolymerization with L- and D-Glutamic Acids

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dc.contributor.authorGonzález Vargas, Camilo
dc.contributor.authorGarcía, Camilo
dc.contributor.authorCelis, Freddy
dc.contributor.authorSalazar, Ricardo
dc.date2018
dc.date.accessioned2019-10-30T14:18:31Z
dc.date.available2019-10-30T14:18:31Z
dc.date.issued2019-10-30
dc.description.abstractA simple and sensitive electrochemical sensor based on glassy carbon electrode modified by electropolymerization with both poly-glutamic acid enantiomers L- and D (GC-PGA) was developed to detect the anti-hypertensive drug hydrochlorotiazide (6-chloro-3,4-di-hydro-2H-1, 2,4-benzothiadiazine-7-sulfonamide-1,1 dioxide, HCTZ) in pharmaceuticals samples. Raman spectroscopy and electrochemical impedance spectroscopy were carried out to characterize L-PGA and D-PGA film. These procedures confirm the production of a polymer through an amide bond and the formation of a film resistant to charge transference in both cases. Also, an increase in the oxidation peak current for HCTZ in Buffer Britton Robinson solution 0,1 M pH 2 was obtained using the modified electrodes. With GC/D-PGA and GC/L-PGA, the peak current increased 2 times compared to unmodified GC, when using differential pulse voltammetry. A novel electroanalytical method for the determination of HCTZ was developed with both modified electrodes, showing a less limit of determination: 0.03186 and 0.01829 mM to GC/L-PGA and GC/D-PGA, respectively, and a less limit of quantification with respect to the GC electrode. The methodology developed was applied in the determination of HCTZ from pharmaceutical formses_ES
dc.formatPDFes_ES
dc.identifier.citationInternational Journal of Electrochemical Science, Vol.13, N°2, 1905-1920, 2018
dc.identifier.doi10.20964/2018.02.10es_ES
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/2047
dc.language.isoeses_ES
dc.sourceInternational Journal of Electrochemical Sciencees_ES
dc.subjectDifferential pulse voltammetryes_ES
dc.subjectElectropolymerizationes_ES
dc.subjectGlassy carbon electrodees_ES
dc.subjectGlutamic Acides_ES
dc.subjectHydrochlorotiazidees_ES
dc.titleDifferential Pulse Voltammetry Determination of Anti-Hypertensive Drug Hydrochlorothiazide in Pharmaceuticals Using Glassy-Carbon Electrode Modified by Electropolymerization with L- and D-Glutamic Acidses_ES
dc.typeArtículo de Revistaes_ES
uct.catalogadorpopes_ES
uct.comunidadIngenieríaes_ES
uct.disciplinaIngeniería Químicaes_ES
uct.indizacionISI - Science Citation Indexes_ES
uct.indizacionSCOPUSes_ES
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