TBA(FeCl3Br) Complex as a Photocatalyst in the Csp3 H Bond Activation in Alcohols for the Synthesis of N-Based Heterocycles
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Date
Authors
Dapper, Luiz H.
Mena, Viviane T.
Rambo, Mateus W.
Santos, Felipe B.
Pineda, Nahum R.
Iglesias, Bernardo A.
Piquini, Paulo C.
Silva, Marcio S.
Lenardao, Eder J.
Penteado, Filipe
Mena, Viviane T.
Rambo, Mateus W.
Santos, Felipe B.
Pineda, Nahum R.
Iglesias, Bernardo A.
Piquini, Paulo C.
Silva, Marcio S.
Lenardao, Eder J.
Penteado, Filipe
Authors
Date
Datos de publicación:
10.1021/acssuschemeng.4c03149
Keywords
Tba(fecl3br) - Fotocatálisis - Heterociclos Basados en Nitrógeno - Benzochalcogenazoles - Quinazolinonas
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Abstract
The TBA(FeCl3Br) complex, formed in situ by the simple mixture of FeCl3 and tetrabutylammonium bromide (TBAB) in MeCN, has been proven to be an outstanding photocatalyst to promote the selective oxidation of alcohols to aldehydes, under blue-light irradiation. Herein, we describe the synthesis of benzochalcogenazoles and quinazolinones by the reaction with suitable ortho-substituted anilines and alcohols under mild conditions. Among the green features, the method reduces the need of derivatization circumventing the use of aldehydes as substrate and allows the isolation of the quinazolinones by precipitation after washing the crude with ethyl ether, avoiding the need of purification by column chromatography.
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Keywords
Tba(fecl3br) , Fotocatálisis , Heterociclos Basados en Nitrógeno , Benzochalcogenazoles , Quinazolinonas
Citation
10.1021/acssuschemeng.4c03149