Efecto de la aplicación de células madre en lesiones tendinosas de equinos deportivos
Efecto de la aplicación de células madre en lesiones tendinosas de equinos deportivos
Authors
Tuemmers Apablaza, Christian
Rebolledo, N.
Aguilera, R.
Rebolledo, N.
Aguilera, R.
Authors
Date
2014-09-04
Datos de publicación:
http://dx.doi.org/10.4067/S0301-732X2012000300002
Keywords
Tendinitis - Células madre mesenquimales - Autólogo - Equinos
Collections
Abstract
La solución para las tendinitis sufridas por los equinos deportivos ha sido, por años, el dilema de los médicos veterinarios que se dedican a tratar este tipo de lesiones. La medicina regenerativa, utilizando células madre del mismo paciente, surge como un método innovador que permite atravesar la barrera de resolución mantenida en el tiempo y con ventajas que superan a las terapias tradicionales, que no proporcionan una recuperación total. Se han descrito la médula ósea y el tejido adiposo como fuentes principales de extracción de células madre. Ambos conllevan un proceso distinto de concentración celular que finalmente termina como un producto que debe ser inyectado en el tendón afectado y, dadas las características típicas de lesión núcleo presentadas en el tejido dañado, puede ser depositado en el centro de éste. El resultado esperado es la regeneración del tendón, sin exceso de tejido fibroso, observando alineación de las fibras tendíneas, disminución de la infiltración inflamatoria y zona hemorrágica. Con un programa de rehabilitación que incluya reposo y ejercicio progresivo, el equino vuelve a su estado competitivo óptimo. La factibilidad de realizar esta terapia en nuestra ubicación geográfica es posible, ya que la técnica de extracción desde ambas fuentes es simple y dentro de las opciones de concentración celular, siendo la del tejido adiposo más sencilla ya que requiere menos elementos y menor tiempo, ejecutándose la terapia en la etapa aguda de la lesión. La utilización de células madre en equinos es un tema de investigación creciente, que promete resultados alentadores.
Finding a cure for tendonitis in sporting horses has been a challenge for veterinarians during a long time. Regenerative medicine using stem cells from the patient has emerged as an innovative method that allows breaking the barriers of finding a resolution that can be maintained over time. Additionally, the benefits surpass those of traditional therapies, which do not facilitate full recovery. Bone marrow and adipose tissue have been described as major sources for stem cell extraction. The use of both tissues involves different processes of cell harvesting and concentration, which eventually yield a product that must be injected into the affected region, or in the center of a typical core lesion. The expected result is the regeneration of the tendon without excess fibrous tissue, properly aligned tendon fibers and decreased inflammatory infiltration and hemorrhage. Following a rehabilitation program that includes resting and progressive exercise, the horse returns to its previous competitive condition. This therapy is feasible because the techniques for extraction from both sources are simple. If the two techniques are compared, adipose tissue extraction is easier because it requires fewer elements and less time. Both therapies, however, can be executed in the acute stage of injury. The use of stem cells in horses is the subject of a growing body research that has already yielded encouraging results.
Finding a cure for tendonitis in sporting horses has been a challenge for veterinarians during a long time. Regenerative medicine using stem cells from the patient has emerged as an innovative method that allows breaking the barriers of finding a resolution that can be maintained over time. Additionally, the benefits surpass those of traditional therapies, which do not facilitate full recovery. Bone marrow and adipose tissue have been described as major sources for stem cell extraction. The use of both tissues involves different processes of cell harvesting and concentration, which eventually yield a product that must be injected into the affected region, or in the center of a typical core lesion. The expected result is the regeneration of the tendon without excess fibrous tissue, properly aligned tendon fibers and decreased inflammatory infiltration and hemorrhage. Following a rehabilitation program that includes resting and progressive exercise, the horse returns to its previous competitive condition. This therapy is feasible because the techniques for extraction from both sources are simple. If the two techniques are compared, adipose tissue extraction is easier because it requires fewer elements and less time. Both therapies, however, can be executed in the acute stage of injury. The use of stem cells in horses is the subject of a growing body research that has already yielded encouraging results.