Pharmacogenomics of vitamin K antagonists

Simple item page
datacite.alternateIdentifier.citationREVISTA MEDICA DE CHILE,Vol.148,1307-1314,2020
datacite.creatorGuzman Oyarzo, Neftali
datacite.creatorVega, Mario
datacite.creatorReyes, Franco
datacite.creatorGuzman-Oyarzo, Dina
datacite.creatorAndaur Rademacher, Marcela
datacite.creatorBoguen, Rodrigo
datacite.creatorLetelier, Pablo
datacite.date2020
datacite.subject.englishAnticoagulants
datacite.subject.englishCoumarins
datacite.subject.englishPharmacogenomic Variants
datacite.titlePharmacogenomics of vitamin K antagonists
dc.date.accessioned2021-04-30T17:07:24Z
dc.date.available2021-04-30T17:07:24Z
dc.description.abstractThere is an important interindividual variability in dose requirement for coumarinic anticoagulants, which could be explained by genetic and non-genetic factors. Among hereditary factors, there are gene polymorphisms that code the therapeutic target and the main enzyme responsible for their metabolism. However, there are other candidate genes that could modulate dose requirements. The is a paucity of pharmacogenomic platforms to determine dose requirements of coumarinics in the Chilean population. Therefore, algorithms considering different variables to adjust individual dosages are required. Herein, we analyze the available evidence about factors that can modify the effects of vitamin K antagonists and that should be incorporated to dosing algorithms.
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/4177
dc.language.isoes
dc.publisherSOC MEDICA SANTIAGO
dc.sourceREVISTA MEDICA DE CHILE
oaire.resourceTypeReview
uct.catalogadorWOS
uct.indizacionSCI
Files
Collections
MigraciĆ³n Web of Science