Sperm quality in mice acutely treated with parathion

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datacite.alternateIdentifier.citationASIAN JOURNAL OF ANDROLOGY,Vol.2,147-150,2000
datacite.creatorSobarzo, C
datacite.creatorBustos-Obregon, E
datacite.date2000
datacite.subject.englishepididymis
datacite.subject.englishspermatozoa
datacite.subject.englishorganophosphorous compounds
datacite.subject.englishagropesticides
datacite.subject.englishspermatogenesis
datacite.titleSperm quality in mice acutely treated with parathion
dc.date.accessioned2021-04-30T16:35:20Z
dc.date.available2021-04-30T16:35:20Z
dc.description.abstractAim: To investigate the toxic effect of a single injection of the organophosphorous agropesticide, parathion, on spermatogenesis in immature male mice. Methods: Seven-day old mice received a single injection of parathion intraperitoneally at a dose of 1/3 LD50. The epididymal sperm count, sperm morphology and chromatin thermal stability were analyzed 28 and 50 days after injection. Results: Sperm counts were decreased and teratozoospermia and thermal denaturation of DNA increased after parathion injection. Sperm parameters were changed to a greater extent in younger animals, denoting a higher lability of spermatogenic process at its beginning. The damages could recover a long time after parathion administration. Conclusion: Organophosphorous agropesticides are testicular toxicants, eliciting reversible cytotoxic and cytogenetic alterations in germ cells.
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3120
dc.language.isoen
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONS
dc.sourceASIAN JOURNAL OF ANDROLOGY
oaire.resourceTypeArticle
uct.catalogadorWOS
uct.indizacionSCI
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