Frequency and Specificity of Red Blood Cell Alloimmunization in Chilean Transfused Patients

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datacite.alternateIdentifier.citationTRANSFUSION MEDICINE AND HEMOTHERAPY,Vol.42,4-7,2015
datacite.alternateIdentifier.doi10.1159/000370136
datacite.creatorCaamano, Jose
datacite.creatorMusante, Evangelina
datacite.creatorContreras, Margarita
datacite.creatorUlloa, Hernan
datacite.creatorReyes, Carolina
datacite.creatorInaipil, Veronica
datacite.creatorSaavedra, Nicolas
datacite.creatorGuzman Oyarzo, Neftali
datacite.date2015
datacite.subject.englishAlloimmunization
datacite.subject.englishUnexpected antibodies
datacite.subject.englishRed blood cell transfusion
datacite.titleFrequency and Specificity of Red Blood Cell Alloimmunization in Chilean Transfused Patients
dc.date.accessioned2021-04-30T17:05:03Z
dc.date.available2021-04-30T17:05:03Z
dc.description.abstractBackground: Alloimmunization is an adverse effect of blood transfusions. In Chile, alloimmunization frequency is not established, and for this reason the aim of this study was to investigate the prevalence and specificity of red blood cell (RBC) alloantibodies in Chilean transfused subjects. Methods: Records from 4,716 multi-transfused patients were analyzed. In these patients, antibody screening was carried out prior to cross-matching with a commercially available two-cell panel by the microcolum gel test, and samples with a positive screen were analyzed for the specificity of the alloantibody with a 16-cell identification panel. Results: The incidence of RBC alloimmunization in transfused patients was 1.02% (48/4,716) with a higher prevalence in women (40/48). We detected 52 antibodies, the most frequent specificities identified were anti-E (30.8%), anti-K (26.9%), anti-D (7.7%), and anti-Fy(a) (5.8%). The highest incidence of alloantibodies was observed in cancer and gastroenterology patients. Conclusion: The data demonstrated a low alloimmunization frequency in Chilean transfused patients, principally associated with antibodies anti-E, anti-K, anti-D, and anti-Fy(a).
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3901
dc.language.isoen
dc.publisherKARGER
dc.sourceTRANSFUSION MEDICINE AND HEMOTHERAPY
oaire.resourceTypeArticle
uct.catalogadorWOS
uct.indizacionSCI
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