Farías, Jorge G.; Zepeda, A.; Castillo, R.; Figueroa Villalobos, Elías; Ademoyero, O.T.; Pulgar, V.M

Chronic hypobaric hypoxia diminishes the expression of base excision repair OGG1 enzymes in spermatozoa

datacite.alternateIdentifier.citation	Andrología, Vol.50, N°2, e12876, 2018	en_US
datacite.alternateIdentifier.doi	10.1111/and.12876	en_US
datacite.creator	Farías, Jorge G.
datacite.creator	Zepeda, A.
datacite.creator	Castillo, R.
datacite.creator	Figueroa Villalobos, Elías
datacite.creator	Ademoyero, O.T.
datacite.creator	Pulgar, V.M
datacite.date	2018
datacite.subject	Infertilidad	en_US
datacite.subject	Estrés oxidativo	en_US
datacite.subject	Daño en el ADN	en_US
datacite.title	Chronic hypobaric hypoxia diminishes the expression of base excision repair OGG1 enzymes in spermatozoa	en_US
dc.date.accessioned	2020-04-06T22:29:05Z
dc.date.available	2020-04-06T22:29:05Z
dc.description.abstract	Hypobaric hypoxia induces DNA damage in rat testicular cells, the production of defective spermatozoids and decreased sperm count, associated with an increase in oxidative stress. 8-Oxoguanine glycosylase (OGG1) enzymes are main members of the base excision repair (BER) system, a DNA repair mechanism. We determined the expression levels of mitochondrial and nuclear OGG1 isoforms in spermatozoa collected from cauda epididymis in rats exposed to chronic hypobaric hypoxia (CHH) for 5, 15 and 30 days. CHH attenuates OGG1 expression in a time-dependent fashion, with a greater reduction in the mitochondrial isoform OGG1-2a (p <.05). Attenuation of the BER system may contribute to DNA damage under hypoxia exposure	en_US
dc.format	PDF	en_US
dc.identifier.uri	http://repositoriodigital.uct.cl/handle/10925/2151
dc.language.iso	en	en_US
dc.source	Andrología	en_US
oaire.resourceType	Artículo de Revista	en_US
uct.catalogador	pop	en_US
uct.comunidad	Ciencias de la Salud	en_US
uct.indizacion	ISI - Science Citation Index	en_US
uct.indizacion	SCOPUS	en_US
uct.nucleos	Núcleo en Producción Alimentaria	en_US