Influence of pH and ionic strength on the antibacterial effect of hyaluronic acid/chitosan films assembled layer-by-layer

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datacite.alternateIdentifier.citationEuropean Polymer Journal, Vol.109, 198-205, 2018en_US
datacite.alternateIdentifier.doi10.1016/j.eurpolymj.2018.09.038en_US
datacite.creatorNascimento, Vicente
datacite.creatorFranca, Carla
datacite.creatorHernández Montelongo, Jacobo
datacite.creatorMachado, Daisy
datacite.creatorLancellotti, Marcelo
datacite.creatorCotta, Mónica
datacite.creatorLanders, Richard
datacite.creatorBeppu, Marisa
datacite.date2018
datacite.subjectPolímeros naturalesen_US
datacite.subjectChitosanen_US
datacite.subjectEfecto antibacterianoen_US
datacite.subjectPHen_US
datacite.subjectPolielectrolitosen_US
datacite.titleInfluence of pH and ionic strength on the antibacterial effect of hyaluronic acid/chitosan films assembled layer-by-layeren_US
dc.date.accessioned2019-12-19T17:05:29Z
dc.date.available2019-12-19T17:05:29Z
dc.description.abstractHyaluronic acid (HA)/chitosan (CHI) films were assembled by LbL using different conditions of pH and ionic strength (IS) in order to obtain stable surfaces to avoid the adhesion and proliferation of Pseudomonas aeruginosa and Staphylococcus aureus. The results showed that pH and IS were key synthesis variables for obtaining different features, such as wettability, thickness and the availability of functional groups. The antibacterial effect was more effective against S. aureus with a reduction of approximately 3, 4, and 1.5 log reduction after 4, 8 and 24 h of culture time, respectively. In the case of P. aeruginosa, the films presented a lower bacterial reduction: 1 log reduction in times evaluated. In conclusion, the results of the antibacterial effect against S. aureus after 24 h, suggest that the HA/CHI films assembled by LbL can protect several substrates, such as biomedical devices, against bacterial proliferationen_US
dc.formatPDFen_US
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/2126
dc.language.isoenen_US
dc.sourceEuropean Polymer Journalen_US
oaire.resourceTypeArtículo de Revistaen_US
uct.catalogadorpopen_US
uct.facultadFacultad de Ingenieríaen_US
uct.indizacionISI - Science Citation Indexen_US
uct.indizacionSCOPUSen_US
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