Influence of pH and ionic strength on the antibacterial effect of hyaluronic acid/chitosan films assembled layer-by-layer

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dc.contributor.authorNascimento, Vicente
dc.contributor.authorFranca, Carla
dc.contributor.authorHernández Montelongo, Jacobo
dc.contributor.authorMachado, Daisy
dc.contributor.authorLancellotti, Marcelo
dc.contributor.authorCotta, Mónica
dc.contributor.authorLanders, Richard
dc.contributor.authorBeppu, Marisa
dc.date2018
dc.date.accessioned2019-12-19T17:05:29Z
dc.date.available2019-12-19T17:05:29Z
dc.description.abstractHyaluronic acid (HA)/chitosan (CHI) films were assembled by LbL using different conditions of pH and ionic strength (IS) in order to obtain stable surfaces to avoid the adhesion and proliferation of Pseudomonas aeruginosa and Staphylococcus aureus. The results showed that pH and IS were key synthesis variables for obtaining different features, such as wettability, thickness and the availability of functional groups. The antibacterial effect was more effective against S. aureus with a reduction of approximately 3, 4, and 1.5 log reduction after 4, 8 and 24 h of culture time, respectively. In the case of P. aeruginosa, the films presented a lower bacterial reduction: 1 log reduction in times evaluated. In conclusion, the results of the antibacterial effect against S. aureus after 24 h, suggest that the HA/CHI films assembled by LbL can protect several substrates, such as biomedical devices, against bacterial proliferationen_US
dc.formatPDFen_US
dc.identifier.citationEuropean Polymer Journal, Vol.109, 198-205, 2018en_US
dc.identifier.doi10.1016/j.eurpolymj.2018.09.038en_US
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/2126
dc.language.isoenen_US
dc.sourceEuropean Polymer Journalen_US
dc.subjectPolímeros naturalesen_US
dc.subjectChitosanen_US
dc.subjectEfecto antibacterianoen_US
dc.subjectPHen_US
dc.subjectPolielectrolitosen_US
dc.titleInfluence of pH and ionic strength on the antibacterial effect of hyaluronic acid/chitosan films assembled layer-by-layeren_US
dc.typeArtículo de Revistaen_US
uct.catalogadorpopen_US
uct.facultadFacultad de Ingenieríaen_US
uct.indizacionISI - Science Citation Indexen_US
uct.indizacionSCOPUSen_US
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