DYNAMIC CHANGES OF HEMATOLOGICAL AND HEMOSTATIC PARAMETERS IN COVID-19 HOSPITALIZED PATIENTS: POTENTIAL ROLE AS SEVERITY BIOMARKERS FOR THE CHILEAN POPULATION
DYNAMIC CHANGES OF HEMATOLOGICAL AND HEMOSTATIC PARAMETERS IN COVID-19 HOSPITALIZED PATIENTS: POTENTIAL ROLE AS SEVERITY BIOMARKERS FOR THE CHILEAN POPULATION
Authors
Letelier, Pablo
Delgado, Hugo
Garrido, Felipe
Quinones, Francisco
San Martin, Andres
Hernandez, Loreto
Garces, Paola
Guzman Oyarzo, Dina
Boguen, Rodrigo
Hernandez, Alfonso
Medina, Gustavo
Schwerter, Patricia
Guzman, Neftali
Delgado, Hugo
Garrido, Felipe
Quinones, Francisco
San Martin, Andres
Hernandez, Loreto
Garces, Paola
Guzman Oyarzo, Dina
Boguen, Rodrigo
Hernandez, Alfonso
Medina, Gustavo
Schwerter, Patricia
Guzman, Neftali
Profesor GuĆa
Authors
Date
Datos de publicaciĆ³n:
10.5937/jomb0-47588
JOURNAL OF MEDICAL BIOCHEMISTRY,Vol.43,556-564,2024
JOURNAL OF MEDICAL BIOCHEMISTRY,Vol.43,556-564,2024
Tipo de recurso
Article
Keywords
Materia geogrƔfica
Collections
Abstract
Background: COVID-19 is still a global health issue, there is limited evidence in South America regarding laboratory biomarkers associated with severe disease. The objective of our study was to identify hematological and hemostatic changes associated with severe COVID-19. Methods: A total of 170 hospitalized patients with COVID19 were included in the study, defining their severity according to established criteria. Demographic, clinical, and laboratory (days 1, 3, 7, 15) data were obtained. We performed a statistical analysis, assuming significance with a value of p < 0.05. We analyzed the correlation between severity and biomarkers and established cut-off values for severe patients through ROC curves, estimating Odds Ratio associated with severe disease. Results: Day 1 was observed significant differences between moderate vs severe patients for leukocytes (WBC), Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and D-dimer, establishing cut-off points for each of them. The markers we found associated to risk of severe disease were WBC ( OR =3.2396; p = 0.0003), NLR ( OR =5.7084; p < 0.0001), PLR ( OR =4.4094; p < 0.0001), Neutrophil ( OR =4.1193; p < 0.0001), D-dimer ( OR =2.7827; p = 0.0124). Conclusions: The results allow to establish basic laboratory biomarkers associated to severe disease, which could be used as prognostic markers.