Oxidative Status in Cats Supplemented with Fish Oil and Challenged with Acetaminophen

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datacite.alternateIdentifier.citationREVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS,Vol.23,388-395,2013
datacite.creatorConstanza Gonzalez, Iris
datacite.creatorNoro, Mirela
datacite.creatorSebastian Galecio, Juan
datacite.creatorChihuailaf VIvánco, Ricardo
datacite.creatorWittwer, Fernando
datacite.date2013
datacite.subject.englishCats
datacite.subject.englishacetaminophen
datacite.subject.englishoxidative stress
datacite.subject.englishfish oil
datacite.titleOxidative Status in Cats Supplemented with Fish Oil and Challenged with Acetaminophen
dc.date.accessioned2021-04-30T16:46:57Z
dc.date.available2021-04-30T16:46:57Z
dc.description.abstractThe aim of this study was to evaluate the energy and oxidative balance in cats supplemented with fish oil and the presence of oxidative and liver damage after a challenge with acetaminophen. Eight sterilized female cats were fed with commercial concentrate and allotted into groups (n = 4), C (control) and AP (8% fish oil in the diet) for 60 days (d). Body weight, body condition, body mass index, blood markers for energy (triacylglycerol, cholesterol, free fatty acids), oxidative damage (malondialdehyde [MDA], erythrocyte osmotic fragility [FOE] and Heinz bodies [HB]) and antioxidative status (glutathione peroxidase, copper, zinc) were determined on d 0, 10, 20, 30, 40, 50 and 60. At d 60, cats were challenged with acetaminophen (100mg/kg po) and blood samples were obtained at 0, 4, 24, 72 and 120 hours to determine oxidative (MDA, HB) and liver damage (ALT and ALP). Supplementation with fish oil increased body weight (16%) without inducing oxidative damage. Meanwhile acetaminophen challenge increased plasma ALP activity and erythrocyte MDA, with higher values of FOE in AP group compared to C. It was concluded that cats supplemented in the diet with 8% fish oil increased their weight without changes in their antioxidant status or susceptibility to oxidative stress. However, an increased erythrocyte osmotic fragility was determined after a challenge with acetaminophen, which is why it is not recommended the use of fish oil as a dietary supplement.
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3427
dc.language.isoes
dc.publisherUNIV ZULIA. FACULTAD CIENCIAS VETERINARIAS
dc.sourceREVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS
oaire.resourceTypeArticle
uct.catalogadorWOS
uct.indizacionSCI
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