Plasma disposition of danofloxacin 2.5% in goats

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dc.contributor.authorErrecalde, Carlos
dc.contributor.authorPrieto, Guillermo F.
dc.contributor.authorLüders Post, Carlos
dc.date2018
dc.date.accessioned2020-06-24T21:02:34Z
dc.date.available2020-06-24T21:02:34Z
dc.description.abstractPharmacokinetic parameters of danofloxacin at 2.5% were determined after intravenous and intramuscular application in adult goat females. Plasma levels were quantified by HPLC with fluorescence detector set at 295 nm excitation and 490 nm emission using mobile phase composed of water, acetonitrile and triethylamine (79:19:1 v/v/v) adjusted to pH 3.0. In each route of application, using plasma concentrations versus time data in each animal, pharmacokinetic parameters were determined with PK Solution 2.0 software. Quantification limit of the assay was 0.0048 µg/ml. The kinetic profile exhibited by danofloxacin in goats was similar to that of fluoroquinolones in domestic animals. The intramuscular application provides rapid absorption, produces a Cmax of 0.36 ± 0.13 µg/ml at 55.1 ± 13.8 minutes, and exhibits wide distribution in the organism and bioavailability (F) of 109.7 ± 19.8%. Danofloxacin showed a slight permanence in the organism, according to the values obtained in t½β = 4.35 hours (EV), 4.32 hours (IM) and in the TMR = 5.9 hours (EV), 6.7 hours (IM). Intramuscular and intravenous application are comparable, but rational use requires dosage adjustment to ensure clinical and therapeutic success, because plasma Cmax/ MIC90 and ABC/ MIC90 ratios of 9 and 41, respectively in relation to MIC90 of M. haemolytica, are insufficient to ensure clinical-microbiological efficacy.en_US
dc.formatPDFen_US
dc.identifier.citationRevista de Investigaciones Veterinarias del Peru, Vol.29, N°2, 479-485en_US
dc.identifier.doi10.15381/rivep.v29i2.14490en_US
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/2247
dc.language.isoenen_US
dc.rightsObra bajo licencia Creative Commons 3.0en_US
dc.sourceRevista de Investigaciones Veterinarias del Perúen_US
dc.subjectMarbofloxacinaen_US
dc.subjectPasteurellum Multocidumen_US
dc.subjectActinobacillus pleuroneumoníaen_US
dc.titlePlasma disposition of danofloxacin 2.5% in goatsen_US
dc.title.alternativeDisposición plasmática de danofloxacina al 2.5% en cabrasen_US
dc.typeArtículo de Revistaen_US
uct.carreraPedagogía en Educación Físicaen_US
uct.catalogadormlmen_US
uct.comunidadRecursos Naturalesen_US
uct.facultadFacultad de Recursos Naturalesen_US
uct.indizacionSCOPUSen_US
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