The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?

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datacite.alternateIdentifier.citationFRONTIERS IN CELLULAR NEUROSCIENCE,Vol.15,,2021
datacite.alternateIdentifier.doi10.3389/fncel.2021.636176
datacite.creatorBustamante-Barrientos, Felipe A.
datacite.creatorMendez-Ruette, Maxs
datacite.creatorOrtloff, Alexander
datacite.creatorLuz-Crawford, Patricia
datacite.creatorRivera, Francisco J.
datacite.creatorFigueroa, Carlos D.
datacite.creatorMolina, Luis
datacite.creatorBatiz, Luis Federico
datacite.date2021
datacite.subject.englishER alpha/beta
datacite.subject.englishGPER1/GPR30
datacite.subject.english17 beta-estradiol
datacite.subject.englishbisphenol A
datacite.subject.englishAlzheimer's disease
datacite.subject.englishParkinson's disease
datacite.subject.englishhormone replacement therapy
datacite.subject.englishneural stem/progenitor cells
datacite.subject.english
datacite.titleThe Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?
dc.date.accessioned2021-10-04T18:54:35Z
dc.date.available2021-10-04T18:54:35Z
dc.description.abstractEstrogens and estrogen-like molecules can modify the biology of several cell types. Estrogen receptors alpha (ER alpha) and beta (ER beta) belong to the so-called classical family of estrogen receptors, while the G protein-coupled estrogen receptor 1 (GPER-1) represents a non-classical estrogen receptor mainly located in the plasma membrane. As estrogen receptors are ubiquitously distributed, they can modulate cell proliferation, differentiation, and survival in several tissues and organs, including the central nervous system (CNS). Estrogens can exert neuroprotective roles by acting as anti-oxidants, promoting DNA repair, inducing the expression of growth factors, and modulating cerebral blood flow. Additionally, estrogen-dependent signaling pathways are involved in regulating the balance between proliferation and differentiation of neural stem/progenitor cells (NSPCs), thus influencing neurogenic processes. Since several estrogen-based therapies are used nowadays and estrogen-like molecules, including phytoestrogens and xenoestrogens, are omnipresent in our environment, estrogen-dependent changes in cell biology and tissue homeostasis have gained attention in human health and disease. This article provides a comprehensive literature review on the current knowledge of estrogen and estrogen-like molecules and their impact on cell survival and neurodegeneration, as well as their role in NSPCs proliferation/differentiation balance and neurogenesis.
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/4387
dc.language.isoen
dc.publisherFRONTIERS MEDIA SA
dc.sourceFRONTIERS IN CELLULAR NEUROSCIENCE
oaire.resourceTypeReview
uct.indizacionSCI
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