Axonal quantification of the white matter association fasciculi in cerebral hemispheres of cow (Bos taurus), pig (Sus scrofa domesticus) and rabbit (Oryctolagus cuniculus)

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datacite.alternateIdentifier.citationFOLIA MORPHOLOGICA,Vol.81,874-883,2022
datacite.alternateIdentifier.doi10.5603/FM.a2021.0116
datacite.creatorGuerrero, M.
datacite.creatorRomero, I
datacite.creatorSandoval, C.
datacite.creatorGaibor Pazmino, A.
datacite.creatorNorona, A.
datacite.creatorZurita, V
datacite.creatordel Sol, M.
datacite.creatorOttone, N. E.
datacite.date2022
datacite.subject.englishaxons
datacite.subject.englishcerebral fasciculi
datacite.subject.englishhistological analysis
datacite.subject.englishmyelin sheaths
datacite.subject.englishwhite matter
datacite.titleAxonal quantification of the white matter association fasciculi in cerebral hemispheres of cow (Bos taurus), pig (Sus scrofa domesticus) and rabbit (Oryctolagus cuniculus)
dc.date.accessioned2023-06-08T15:48:07Z
dc.date.available2023-06-08T15:48:07Z
dc.description.abstractBackground: Cerebral white matter consists mainly of axons surrounded by my-elin sheaths, which are grouped to form association, commissural, and projection fasciculi. The aim of our work was to quantify and compare under the microscope the axons of the white matter association fasciculi in the cerebral hemispheres of cow (Bos taurus), pig (Sus scrofa domesticus) and rabbit (Oryctolagus cuniculus) indirectly by identification of their myelin sheaths.Materials and methods: The samples were taken from 30 cerebral hemispheres: 10 cow, 10 pig and 10 rabbit (15 right and 15 left). They were obtained following a protocol based on the Talairach-Tournoux coordinate system for human and primate brains. The slides were stained with Luxol Fast Blue, observed by optical microscopy, and photographed at 600x. Samples were also prepared for obser-vation in scanning transmission electron microscopy with osmium tetroxide. The myelin sheaths/axons were counted with the ImageJ software.Results: Statistically significant differences in the number of myelin sheaths per 410 mu m2 were found in the inferior and superior longitudinal fasciculi between the left and right hemispheres of cows, with predominance of the right hemisphere; and in the inferior occipitofrontal fasciculus of the rabbit with predominance of the left hemisphere.Conclusions: The use of animal models for experiments in the cerebral fasciculi, especially pig, could give us a greater understanding of the behaviour of demy-elinating and neurodegenerative diseases in humans. (Folia Morphol 2022; 81, 4: 874-883)
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5220
dc.language.isoen
dc.publisherVIA MEDICA
dc.sourceFOLIA MORPHOLOGICA
oaire.resourceTypeArticle
uct.indizacionSCI
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