Farmacogenómica de los anticoagulantes orales: la importancia de establecer algoritmos de dosificación en población chilena
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Date
2020
Authors
Guzmán Oyarzo, Neftalí
Vega Sanhueza, Mario
Reyes Cadagán, Franco
Guzmán Oyarzo, Dina
Andaur Rademacher, Marcela
Boguen Ojeda, Rodrigo
Letelier Arias, Pablo
Vega Sanhueza, Mario
Reyes Cadagán, Franco
Guzmán Oyarzo, Dina
Andaur Rademacher, Marcela
Boguen Ojeda, Rodrigo
Letelier Arias, Pablo
Authors
Date
2020
Datos de publicación:
10.4067/S0034-98872020000901307
Keywords
Pharmacogenomic variants - Coumarins - Anticoagulants - Anticoagulantes - Cumarina - Farmacogenética
Collections
Abstract
There is an important interindividual variability in dose requirement for coumarinic anticoagulants, which could be explained by genetic and non-genetic factors. Among hereditary factors, there are gene polymorphisms that code the therapeutic target and the main enzyme responsible for their metabolism. However, there are other candidate genes that could modulate dose requirements. The is a paucity of pharmacogenomic platforms to determine dose requirements of coumarinics in the Chilean population. Therefore,
algorithms considering different variables to adjust individual dosages are
required. Herein, we analyze the available evidence about factors that can
modify the effects of vitamin K antagonists and that should be incorporated
to dosing algorithms
Description
Keywords
Pharmacogenomic variants , Coumarins , Anticoagulants , Anticoagulantes , Cumarina , Farmacogenética
Citation
10.4067/S0034-98872020000901307