A simple electroanalytical methodology for determination of zaleplon by adsorptive stripping voltammetry in oral fluids

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datacite.alternateIdentifier.citationMICROCHEMICAL JOURNAL,Vol.193,2023
datacite.alternateIdentifier.doi10.1016/j.microc.2023.109256
datacite.creatorAguilera, Scarlett
datacite.creatorFlores, Erick
datacite.creatorSegura, Rodrigo
datacite.creatorBarrientos, Herna
datacite.creatorMarquez, Paulina
datacite.creatorGarcia, Camilo
datacite.creatorMatamala Troncoso, Felipe
datacite.creatorPizarro, Jaime
datacite.creatorAguirre, Maria
datacite.date2023
datacite.subject.englishZaleplon
datacite.subject.englishZ-drugs
datacite.subject.englishSynthetics oral fluids
datacite.subject.englishStripping voltammetry
datacite.titleA simple electroanalytical methodology for determination of zaleplon by adsorptive stripping voltammetry in oral fluids
dc.date.accessioned2024-05-27T18:27:52Z
dc.date.available2024-05-27T18:27:52Z
dc.description.abstractA glassy carbon electrode (GCE), modified with reduced graphene oxide (ErGO) (ErGO/GCE) was prepared for the determination of zaleplon, a common hypnotic pharmaceutical in synthetics and oral fluids. The modified electrode was evaluated using cyclic voltammetry, Raman spectroscopy, and scanning electrochemical microscopy (SECM). The electroanalytical studies were developed by square wave adsorptive stripping voltammetry (SW-AdSV) and parameters such as pH, accumulation potential, deposition time, and current response were optimized to determine zaleplon in Britton Robinson buffer. The validation was made using saliva-certified reference materials (Fusayama/Meyer Artificial Saliva and Artificial Saliva for Pharmaceutical Research showing good accuracy and reproducibility. The ErGO/GCE system showed a linear response between 10 and 130 mu g/L at pH 10.0. The limit of detection was 5.30 mu g L-1. The methodology was applied in the determination of zaleplon in saliva samples, obtaining excellent results (RSD < 10%), allowing the sensitive detection of zaleplon.
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5901
dc.language.isoen
dc.publisherELSEVIER
dc.sourceMICROCHEMICAL JOURNAL
oaire.resourceTypeArticle
uct.indizacionSCI
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