Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity

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datacite.alternateIdentifier.citationBIOMOLECULES,Vol.14,2024
datacite.alternateIdentifier.doi10.3390/biom14070867
datacite.creatorVillegas, Cecilia
datacite.creatorCortez, Nicole
datacite.creatorOgundele, Ayorinde Victor
datacite.creatorBurgos, Viviana
datacite.creatorPardi, Paulo Celso
datacite.creatorCabrera Pardo, Jaime R.
datacite.creatorPaz, Cristian
datacite.date2024
datacite.subject.englishrosmarinic acid
datacite.subject.englishchemotherapy adjuvant
datacite.subject.englishcancer resistance
datacite.subject.englishchemoprotection
datacite.titleTherapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
dc.date.accessioned2024-09-10T18:47:10Z
dc.date.available2024-09-10T18:47:10Z
dc.description.abstractChemotherapeutic drugs and radiotherapy are fundamental treatments to combat cancer, but, often, the doses in these treatments are restricted by their non-selective toxicities, which affect healthy tissues surrounding tumors. On the other hand, drug resistance is recognized as the main cause of chemotherapeutic treatment failure. Rosmarinic acid (RA) is a polyphenol of the phenylpropanoid family that is widely distributed in plants and vegetables, including medicinal aromatic herbs, consumption of which has demonstrated beneficial activities as antioxidants and anti-inflammatories and reduced the risks of cancers. Recently, several studies have shown that RA is able to reverse cancer resistance to first-line chemotherapeutics, as well as play a protective role against toxicity induced by chemotherapy and radiotherapy, mainly due to its scavenger capacity. This review compiles information from 56 articles from Google Scholar, PubMed, and ClinicalTrials.gov aimed at addressing the role of RA as a complementary therapy in cancer treatment.
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5944
dc.language.isoen
dc.publisherMDPI
dc.sourceBIOMOLECULES
oaire.resourceTypeReview
uct.indizacionSCI
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