Obesity Is Associated with Changes in Laboratory Biomarkers in Chilean Patients Hospitalized with COVID-19
Obesity Is Associated with Changes in Laboratory Biomarkers in Chilean Patients Hospitalized with COVID-19
Authors
Viscardi, Sharon
Marileo, Luis
Delgado, Hugo
San Martin, Andres
Hernandez, Loreto
Garces, Paola
Guzman Oyarzo, Dina
Boguen, Rodrigo
Medina, Gustavo
Letelier, Pablo
Villano, Ines
Guzman, Neftali
Marileo, Luis
Delgado, Hugo
San Martin, Andres
Hernandez, Loreto
Garces, Paola
Guzman Oyarzo, Dina
Boguen, Rodrigo
Medina, Gustavo
Letelier, Pablo
Villano, Ines
Guzman, Neftali
Profesor Guía
Authors
Date
Datos de publicación:
10.3390/jcm12103392
JOURNAL OF CLINICAL MEDICINE,Vol.12,2023
JOURNAL OF CLINICAL MEDICINE,Vol.12,2023
Tipo de recurso
Article
Keywords
Materia geográfica
Collections
Abstract
Background and aims: It is reported that patients with obesity are more frequently hospitalized for COVID-19, and evidence exists that obesity is a risk factor, regardless of other comorbidities. The objective of this study was to evaluate the association of obesity with changes in laboratory biomarkers in hospitalized Chilean patients. Materials and methods: A total of 202 hospitalized patients (71 with obesity and 131 without obesity) with a diagnosis of COVID-19 were included in the study. Demographic, clinical, and laboratory (days 1, 3, 7, 15) data were obtained. We performed a statistical analysis, assuming significance with a value of p < 0.05. Results: Significant differences in chronic respiratory pathology are observed between patients with and without obesity. The inflammatory markers CPR, ferritin, NLR, and PLR are elevated during the evaluated period, while changes in leukocyte populations are present on day 1 (eosinophils) and day 3 (lymphocytes). Finally, a persistent elevation of D-dimer level is observed, presenting significant differences on day 7 between patients with and without obesity. Obesity had a positive correlation with admission to the critical patient unit, invasive mechanical ventilation, and length of hospital stay. Conclusion: Patients with obesity hospitalized for COVID-19 present marked elevations of inflammatory and hemostasis parameters, with a correlation between obesity, changes in laboratory biomarkers, and the risk of adverse clinical outcomes also observed.