Effects of resistance exercise training on redox homeostasis in older adults. Asystematic review and meta-analysis
Effects of resistance exercise training on redox homeostasis in older adults. Asystematic review and meta-analysis
Authors
Cuyul Vásquez, Iván
Berríos Contreras, Lily
Soto Fuentes, Stephanie
Hunter Echeverría, Karina
Marzuca Nassr, Gabriel
Berríos Contreras, Lily
Soto Fuentes, Stephanie
Hunter Echeverría, Karina
Marzuca Nassr, Gabriel
Authors
Date
Datos de publicación:
10.1016/j.exger.2020.111012
Keywords
Resistance exercise training - Aging - Oxidative stress - Antioxidants
Collections
Abstract
Background
Resistance exercise training (RET) has proven effective at reducing the risk of chronic disease in older populations, and it appears to regulate redox homeostasis.
Aims
To determine the effects of RET on redox homeostasis in older people.
Study design
A systematic review and meta-analysis of randomized clinical trials identified by searching MEDLINE, Web of Science, EMBASE, Sportdiscus, LILACS, CENTRAL and CINAHL. We included studies of subjects aged 65 years or older, with or without pathologies, and including RET metrics with quantified molecular oxidation and antioxidant capacity outcomes.
Results
Fifteen studies were included in this review. Agreement between reviewers reached a kappa value of 0.725. There were a total of 614 participants, with an average age of 68.1 years. Five (for molecular oxidation markers) and three (for antioxidant capacity markers) studies included data that quantified the effects of RET on homeostasis redox. The results of the meta-analysis showed that there were no differences in the molecular oxidation markers (SMD = −0.26; 95% CI = −0.57 to 0.05; P = 0.10; I2 = 0%) and antioxidant capacity markers (SMD = 0.53; 95% CI = −0.20 to 1.26; P = 0.16; I2 = 71.5%) in healthy older people after a RET of 8–24 weeks compared to non-intervention.
Conclusions
Based on a small number of studies of low methodological quality, this systematic review with meta-analysis suggests that RET is not effective at reducing molecular oxidation markers in healthy older people. More research is needed on the effects of RET on redox homeostasis in older people.