Relationship Between Plasma Leptin Levels and Airflow Limitation in the Small and Medium Airways in Young Adults
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Date
Authors
Muñoz-Cofre, Rodrigo
Rojas-Mancilla, Edgardo
Lizana, Pablo A.
Escobar-Cabello, Máximo
García-Herrera, Claudio M.
Conei-Valencia, Daniel
Valenzuela-Aedo, Fernando
Soto-Rodríguez, Francisco Javier
Del Sol, Mariano
Rojas-Mancilla, Edgardo
Lizana, Pablo A.
Escobar-Cabello, Máximo
García-Herrera, Claudio M.
Conei-Valencia, Daniel
Valenzuela-Aedo, Fernando
Soto-Rodríguez, Francisco Javier
Del Sol, Mariano
Authors
Date
Datos de publicación:
10.3390/jcm14051624
Keywords
Airflow - Airway - Body Composition - Leptin - Young Adult - Leptin - Adult - Age - Airflow Limitation - Airway Resistance - Article - Body Composition - Body Fat Percentage - Body Mass - Controlled Study - Enzyme Linked Immunosorbent Assay - Fat Free Mass - Female - Forced Expiratory Flow - Forced Expiratory Volume - Hormone Blood Level - Human - Lung Function - Male - Respiratory Airflow - Respiratory Tract Parameters - Sex Difference - Trunk - Young Adult
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Abstract
Background/Objectives: To determine the relationship between plasma leptin levels and airflow limitation (AFL) in the small and medium airways of young adults according to their body composition (BC).
Methods: To determine AFL, the following measurements were taken: forced expiratory volume in the first second (FEV₁), forced expiratory flow between 25–75% (FEF₂₅–₇₅%), airway resistance (Raw), and specific airway resistance (sRaw). The measured BC variables were body mass index (BMI), body fat percentage (%BF), trunk fat percentage (TF%), and fat-free mass (FFM). Plasma leptin was measured using the ELISA technique.
Results: In total, 83 participants (40 male and 43 female), aged 21.55 ± 2.08 years, were evaluated. Leptin was significantly higher in women than in men (p < 0.01). When relating leptin to lung function variables, FEV₁ and FEF₂₅–₇₅% showed a significant inverse relationship (p < 0.01), while Raw and sRaw showed a direct and significant relationship (p < 0.01). Female participants with a %BF and leptin higher than their p75 were observed to have a higher risk of increased sRaw (OR = 1.0; OR = 1.15, respectively), regardless of age, and participants with an FFM% higher than their p75 had a lower risk of increased sRaw (OR = 0.71), regardless of gender and age.
Conclusions: There is an inverse relationship between FEV₁, FEF₂₅–₇₅%, and a direct relationship between Raw and sRaw with leptin. For female participants with higher %BF, higher FFM%, and leptin, the risk of developing increased Raw and sRaw was found to be modified.
© 2025 Elsevier B.V. All rights reserved.
Description
Keywords
Airflow , Airway , Body Composition , Leptin , Young Adult , Leptin , Adult , Age , Airflow Limitation , Airway Resistance , Article , Body Composition , Body Fat Percentage , Body Mass , Controlled Study , Enzyme Linked Immunosorbent Assay , Fat Free Mass , Female , Forced Expiratory Flow , Forced Expiratory Volume , Hormone Blood Level , Human , Lung Function , Male , Respiratory Airflow , Respiratory Tract Parameters , Sex Difference , Trunk , Young Adult
Citation
10.3390/jcm14051624