Oxidized hyaluronic acid/adipic acid dihydrazide hydrogel as cell microcarriers for tissue regeneration applications

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datacite.alternateIdentifier.citationE-POLYMERS,Vol.22,949-958,2022
datacite.alternateIdentifier.doi10.1515/epoly-2022-0086
datacite.creatorFranca, Carla Giometti
datacite.creatorLeme, Krissia Caroline
datacite.creatorMalheiros Luzo, Angela Cristina
datacite.creatorHernandez Montelongo, Jacobo
datacite.creatorAndrade Santana, Maria Helena
datacite.date2022
datacite.subject.englishoxidized hyaluronic acid
datacite.subject.englishadipic dihydrazide
datacite.subject.englishhydrogel microcarriers
datacite.subject.englishinjectability
datacite.subject.englishtissue engineering
datacite.titleOxidized hyaluronic acid/adipic acid dihydrazide hydrogel as cell microcarriers for tissue regeneration applications
dc.date.accessioned2023-06-08T15:48:07Z
dc.date.available2023-06-08T15:48:07Z
dc.description.abstractHyaluronic acid (HA) is a biopolymer present in various human tissues, whose degradation causes tissue damage and diseases. The oxidized hyaluronic acid/adipic acid dihydrazide (oxi-HA/ADH) hydrogels have attracted attention due to their advantages such as thermosensitivity, injectability, in situ gelation, and sterilization. However, studies are still scarce in the literature as microcarriers. In that sense, this work is a study of oxi-HA/ADH microparticles of 215.6 & PLUSMN; 2.7 mu m obtained by high-speed shearing (18,000 rpm at pH 7) as cell microcarriers. Results showed that BALB/c 3T3 fibroblasts and adipose mesenchymal stem cells (h-AdMSC) cultured on the oxi-HA/ADH microcarriers presented a higher growth of both cells in comparison with the hydrogel. Moreover, the extrusion force of oxi-HA/ADH microparticles was reduced by 35% and 55% with the addition of 25% and 75% HA fluid, respectively, thus improving its injectability. These results showed that oxi-HA/ADH microcarriers can be a potential injectable biopolymer for tissue regeneration applications.
dc.identifier.urihttps://repositoriodigital.uct.cl/handle/10925/5219
dc.language.isoen
dc.publisherDE GRUYTER POLAND SP Z O O
dc.sourceE-POLYMERS
oaire.resourceTypeArticle
uct.indizacionSCI
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