Effect of Sedentary behaviors on the Interaction Between the FTO Gene and Adiposity Levels in Chilean Adults - Results from the GENADIO Study
Effect of Sedentary behaviors on the Interaction Between the FTO Gene and Adiposity Levels in Chilean Adults - Results from the GENADIO Study
Authors
Celis Morales, Carlos
Villagran, Marcelo
Mardones, Lorena
Martinez Sanguinetti, Maria Adela
Leiva Ordonez, Ana Maria
Carrasco Marin, Fernanda
Ulloa, Natalia
Martorell, Miquel
Lasserre Laso, Nicole
Diaz Martinez, Ximena
Cigarroa, Igor
Concha Cisternas, Yeny
Troncoso Pantoja, Claudia
Lanuza, Fabian
Vasquez Gomez, Jaime
Parra Soto, Solange
Petermann Rocha, Fanny
Villagran, Marcelo
Mardones, Lorena
Martinez Sanguinetti, Maria Adela
Leiva Ordonez, Ana Maria
Carrasco Marin, Fernanda
Ulloa, Natalia
Martorell, Miquel
Lasserre Laso, Nicole
Diaz Martinez, Ximena
Cigarroa, Igor
Concha Cisternas, Yeny
Troncoso Pantoja, Claudia
Lanuza, Fabian
Vasquez Gomez, Jaime
Parra Soto, Solange
Petermann Rocha, Fanny
Profesor GuĆa
Authors
Date
Datos de publicaciĆ³n:
REVISTA MEDICA DE CHILE,Vol.151,980-991,2023
Tipo de recurso
Article
Keywords
Materia geogrƔfica
Collections
Abstract
Background: The Fat-mass and obesity-associated-gene (FTO gene) and sedentary behavior time are associated with obesity. However, whether sedentary behavior time can modify the genetic predisposition to obesity in the Chilean population is unknown. Therefore, this study investigated the association between sedentary behavior, adiposity markers, and the FTO gene. Methods: This cross-sectional study included 409 participants from the Genes, Environment, Diabetes, and Obesity (GENADIO) study. Adiposity markers studied included body weight, body mass index (BMI), waist circumference (WC), and fat mass. Sedentary behaviors were measured using accelerometers. Using multiple regression, we evaluated the interaction between sedentary behaviors and the FTO gene (rs9939609) on adiposity markers. Results: Sedentary behaviors and the FTO genotype were positively associated with higher body weight, BMI, WC, and fat mass. However, the association between time of sedentary behavior and adiposity markers was higher in carriers of the risk variant for the FTO gene. For each hour of increment in sedentary behaviors, body weight increases by 1.36 kg ([95% CI: 0.27; 2.46], p = 0.015) and 2.95 kg ([95%CI: 1.24; 4.65], p = 0.001) in non-risk carriers (TT) versus risk carriers (AA), respectively. We observed similar results for WC, BMI, and body fat, but the interaction was significant only for WC. Conclusion: The association between sedentary behaviors and adiposity markers, especially body weight and WC, is higher in individuals who carry the risk variant of the FTO gene.