Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer

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dc.contributor.authorRiquelme, Ismael
dc.contributor.authorLetelier, Pablo
dc.contributor.authorRiffo Campos, Angela L.
dc.contributor.authorBrebi, Priscilla
dc.contributor.authorCarlos Roa, Juan
dc.date2016
dc.date.accessioned2021-04-30T16:47:00Z
dc.date.available2021-04-30T16:47:00Z
dc.description.abstractGastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in gastric cancer patients. Although the mechanisms of drug resistance have been broadly studied, the regulation of these mechanisms has not been completely understood. Accumulating evidence has recently highlighted the role of microRNAs in the development and maintenance of drug resistance due to their regulatory features in specific genes involved in the chemoresistant phenotype of malignancies, including gastric cancer. This review summarizes the current knowledge about the miRNAs' characteristics, their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment in resistant gastric cancer.
dc.identifier.citationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,Vol.17,,2016
dc.identifier.doi10.3390/ijms17030424
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3479
dc.language.isoen
dc.publisherMDPI
dc.sourceINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
dc.subject.englishmicroRNAs
dc.subject.englishdrug resistance
dc.subject.englishgastric cancer
dc.titleEmerging Role of miRNAs in the Drug Resistance of Gastric Cancer
dc.typeReview
uct.catalogadorWOS
uct.indizacionSCI
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