Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer

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datacite.alternateIdentifier.citationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,Vol.17,,2016
datacite.alternateIdentifier.doi10.3390/ijms17030424
datacite.creatorRiquelme, Ismael
datacite.creatorLetelier, Pablo
datacite.creatorRiffo Campos, Angela L.
datacite.creatorBrebi, Priscilla
datacite.creatorCarlos Roa, Juan
datacite.date2016
datacite.subject.englishmicroRNAs
datacite.subject.englishdrug resistance
datacite.subject.englishgastric cancer
datacite.titleEmerging Role of miRNAs in the Drug Resistance of Gastric Cancer
dc.date.accessioned2021-04-30T16:47:00Z
dc.date.available2021-04-30T16:47:00Z
dc.description.abstractGastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in gastric cancer patients. Although the mechanisms of drug resistance have been broadly studied, the regulation of these mechanisms has not been completely understood. Accumulating evidence has recently highlighted the role of microRNAs in the development and maintenance of drug resistance due to their regulatory features in specific genes involved in the chemoresistant phenotype of malignancies, including gastric cancer. This review summarizes the current knowledge about the miRNAs' characteristics, their regulation of the genes involved in chemoresistance and their potential as targeted therapies for personalized treatment in resistant gastric cancer.
dc.identifier.urihttp://repositoriodigital.uct.cl/handle/10925/3479
dc.language.isoen
dc.publisherMDPI
dc.sourceINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
oaire.resourceTypeReview
uct.catalogadorWOS
uct.indizacionSCI
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